Peroxisome Proliferator-Activated Receptor-γ in Thyroid Autoimmunity

Figure 1

Several cell types (e.g., thyrocytes), under the influence of cytokines (such as IFN-γ and TNF-α), can modulate the autoimmune response through the production of CXCL9, CXCL10, and CXCL11. These chemokines can induce migration into different tissues of Th1 lymphocytes, which in turn secrete more IFN-γ and TNF-α, further stimulating the chemokine production by the target cells, thus perpetuating the autoimmune cascade. PPAR-γ agonists play an inhibitory role in this process.