Zebrafish as a Model to Study the Role of Peroxisome Proliferating-Activated Receptors in Adipogenesis and Obesity

Table 3

Comparison of PPARs between human, mouse, and zebrafish.

PPAR	Human	Mouse	Zebrafish
PPARA
Genes	1	1	2
Splice variants	1	1	1 per gene
Isoforms	1	1	1 per gene
Size (cds, bp)	1,407	1,407	pparaa: 1,413; pparab: 1,380
Protein similarity to zebrafish	67% for pparaa; 74% for pparab	65% for pparaa; 71% for pparab
PPARD
Genes	1	1	2
Splice variants	1	1	1 per gene
Isoforms	1	1	1 per gene
Size (cds, bp)	1,326	1,323	pparda: 1,491; ppardb: 1,554
Protein similarity to zebrafish	71% for pparda; 73% for ppardb	70% for pparda; 73% for ppardb
PPARG
Genes	1	1	1
Splice variants	4	1	1
Isoforms	2	2	1
Size (cds, bp)	PPARG1 = 1,434; PPARG2 = 1,518	PPARG1 = 1,428; PPARG2 = 1,518	pparg: 1,584
Protein similarity to zebrafish	67%	67%