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PPAR Research
Volume 2015, Article ID 480348, 9 pages
http://dx.doi.org/10.1155/2015/480348
Research Article

Nitrooleic Acid Attenuates Lipid Metabolic Disorders and Liver Steatosis in DOCA-Salt Hypertensive Mice

1Department of Nephrology, Provincial Hospital Affiliated to Shandong University, No. 324 Jingwu Road, Jinan, Shandong 250013, China
2Department of Internal Medicine, University of Utah and Salt Lake Veterans Affairs Medical Center, Salt Lake City, UT 84112, USA

Received 10 August 2014; Accepted 14 September 2014

Academic Editor: Yue Zhang

Copyright © 2015 Haiping Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Hermida Ameijeiras, J. E. Lopez Paz, M. Pena Seijo et al., “Lipid profile in hypertensive patients treated with lipid lowering therapy,” Journal of Hypertension, vol. 28, pp. 378–379, 2010. View at Publisher · View at Google Scholar
  2. D. Sarkar, S. A. Latif, M. M. Uddin et al., “Studies on serum lipid profile in hypertensive patient,” Mymensingh Medical Journal, vol. 16, no. 1, pp. 70–76, 2007. View at Google Scholar · View at Scopus
  3. A. Girard, S. Madani, E. S. El Boustani, J. Belleville, and J. Prost, “Changes in lipid metabolism and antioxidant defense status in spontaneously hypertensive rats and Wistar rats fed a diet enriched with fructose and saturated fatty acids,” Nutrition, vol. 21, no. 2, pp. 240–248, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Nakano, N. Inoue, Y. Sato et al., “LOX-1 mediates vascular lipid retention under hypertensive state,” Journal of Hypertension, vol. 28, no. 6, pp. 1273–1280, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. D. Levy, A. Höke, and D. W. Zochodne, “Local expression of inducible nitric oxide synthase in an animal model of neuropathic pain,” Neuroscience Letters, vol. 260, no. 3, pp. 207–209, 1999. View at Publisher · View at Google Scholar · View at Scopus
  6. S. Naureckiene, W. Edris, S. K. Ajit et al., “Use of a murine cell line for identification of human nitric oxide synthase inhibitors,” Journal of Pharmacological and Toxicological Methods, vol. 55, no. 3, pp. 303–313, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. T. Yang, H. Wang, H. Liu, Z. Jia, and G. Guan, “Effects of endogenous PPAR agonist nitro-oleic acid on metabolic syndrome in obese Zucker rats,” PPAR Research, vol. 2010, Article ID 601562, 7 pages, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. M. S. Rangel-Frausto, D. Pittet, M. Costigan, T. Hwang, C. S. Davis, and R. P. Wenzel, “The natural history of the systemic inflammatory response syndrome (SIRS): a prospective study,” Journal of the American Medical Association, vol. 273, no. 2, pp. 117–123, 1995. View at Publisher · View at Google Scholar · View at Scopus
  9. C. Veeramani, K. S. Al-Numair, G. Chandramohan, M. A. Alsaif, and K. V. Pugalendi, “Antihyperlipidemic effect of Melothria maderaspatana leaf extracts on DOCA-salt induced hypertensive rats,” Asian Pacific Journal of Tropical Medicine, vol. 5, no. 6, pp. 434–439, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. J. O. Lundberg, M. T. Gladwin, A. Ahluwalia et al., “Nitrate and nitrite in biology, nutrition and therapeutics,” Nature Chemical Biology, vol. 5, no. 12, pp. 865–869, 2009. View at Publisher · View at Google Scholar
  11. H. Wang, H. Liu, Z. Jia et al., “Nitro-oleic acid protects against endotoxin-induced endotoxemia and multiorgan injury in mice,” The American Journal of Physiology—Renal Physiology, vol. 298, no. 3, pp. F754–F762, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. J. Zhang, L. Villacorta, L. Chang et al., “Nitro-oleic acid inhibits angiotensin II-induced hypertension,” Circulation Research, vol. 107, no. 4, pp. 540–548, 2010. View at Publisher · View at Google Scholar
  13. M. P. Cole, T. K. Rudolph, N. K. Khoo, and P. M. Bauer, “Nitro-fatty acid inhibition of neointima formation after endoluminal vessel injury,” Circulation Research, vol. 105, pp. 965–972, 2009. View at Publisher · View at Google Scholar
  14. S.-L. Lin, Y.-M. Chen, W.-C. Chiang, K.-D. Wu, and T.-J. Tsai, “Effect of pentoxifylline in addition to losartan on proteinuria and GFR in CKD: a 12-month randomized trial,” The American Journal of Kidney Diseases, vol. 52, no. 3, pp. 464–474, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. Liu, Z. Jia, S. Liu et al., “Combined losartan and nitro-oleic acid remarkably improves diabetic nephropathy in mice,” American Journal of Physiology: Renal Physiology, vol. 305, no. 11, pp. F1555–F1562, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. P. Prahalathan, M. Saravanakumar, and B. Raja, “The flavonoid morin restores blood pressure and lipid metabolism in DOCA-salt hypertensive rats,” Redox Report, vol. 17, no. 4, pp. 167–175, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. C. Veeramani, K. S. Al-Numair, G. Chandramohan, M. A. Alsaif, and K. V. Pugalendi, “Antihyperlipidemic effect of Melothria maderaspatana leaf extracts on DOCA-salt induced hypertensive rats,” Asian Pacific Journal of Tropical Medicine, vol. 5, no. 6, pp. 434–439, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. J. Fu, S. Gaetani, F. Oveisi et al., “Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α,” Nature, vol. 425, no. 6953, pp. 90–93, 2003. View at Publisher · View at Google Scholar · View at Scopus
  19. S. Terrazzino, F. Berto, M. D. Carbonare et al., “Stearoylethanolamide exerts anorexic effects in mice via down-regulation of liver stearoyl-coenzyme A desaturase-1 mRNA expression,” The FASEB Journal, vol. 18, no. 13, pp. 1580–1582, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. G. Astarita, B. C. Rourke, J. B. Andersen et al., “Postprandial increase of oleoylethanolamide mobilization in small intestine of the Burmese python (Python molurus),” The American Journal of Physiology—Regulatory Integrative and Comparative Physiology, vol. 290, no. 5, pp. R1407–R1412, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. G. H. Allcock, M. Hukkanen, J. M. Polak, J. S. Pollock, and D. M. Pollock, “Increased nitric oxide synthase-3 expression in kidneys of deoxycorticosterone acetate-salt hypertensive rats,” Journal of the American Society of Nephrology, vol. 10, no. 11, pp. 2283–2289, 1999. View at Google Scholar · View at Scopus
  22. N. Hernández, S. H. Torres, J. B. de Sanctis, and A. Sosa, “Metabolic changes in DOCA-salt hypertensive rats,” Research Communications in Molecular Pathology and Pharmacology, vol. 108, no. 3-4, pp. 201–211, 2000. View at Google Scholar
  23. P. de Lange, A. Lombardi, E. Silvestri, F. Goglia, A. Lanni, and M. Moreno, “Peroxisome proliferator-activated receptor delta: a conserved director of lipid homeostasis through regulation of the oxidative capacity of muscle,” PPAR Research, vol. 2008, Article ID 172676, 7 pages, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. I. P. Torra, G. Chinetti, C. Duval, J.-C. Fruchart, and B. Staels, “Peroxisome proliferator-activated receptors: from transcriptional control to clinical practice,” Current Opinion in Lipidology, vol. 12, no. 3, pp. 245–254, 2001. View at Publisher · View at Google Scholar · View at Scopus
  25. G. D. Barish, V. A. Narkar, and R. M. Evans, “PPARδ: a dagger in the heart of the metabolic syndrome,” Journal of Clinical Investigation, vol. 116, no. 3, pp. 590–597, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. G. D. Barish, “Peroxisome proliferator-activated receptors and liver X receptors in atherosclerosis and immunity,” Journal of Nutrition, vol. 136, no. 3, pp. 690–694, 2006. View at Google Scholar · View at Scopus
  27. V. Emilsson, J. O'Dowd, S. Wang et al., “The effects of rexinoids and rosiglitazone on body weight and uncoupling protein isoform expression in the zucker fa/fa rat,” Metabolism: Clinical and Experimental, vol. 49, no. 12, pp. 1610–1615, 2000. View at Publisher · View at Google Scholar · View at Scopus
  28. T. E. Akiyama, C. J. Nicol, C. Fievet et al., “Peroxisome proliferator-activated receptor-α regulates lipid homeostasis, but is not associated with obesity. Studies with congenic mouse lines,” The Journal of Biological Chemistry, vol. 276, no. 42, pp. 39088–39093, 2001. View at Publisher · View at Google Scholar · View at Scopus
  29. Y. Guan, “Peroxisome proliferator-activated receptor family and its relationship to renal complications of the metabolic syndrome,” Journal of the American Society of Nephrology, vol. 15, no. 11, pp. 2801–2815, 2004. View at Publisher · View at Google Scholar · View at Scopus
  30. J. R. Jones, C. Barrick, K.-A. Kim et al., “Deletion of PPARγ in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 17, pp. 6207–6212, 2005. View at Publisher · View at Google Scholar · View at Scopus
  31. R. Komers and A. Vrána, “Thiazolidinediones—tools for the research of metabolic syndrome X,” Physiological Research, vol. 47, no. 4, pp. 215–225, 1998. View at Google Scholar · View at Scopus
  32. F. Lalloyer, B. Vandewalle, F. Percevault et al., “Peroxisome proliferator-activated receptor α improves pancreatic adaptation to insulin resistance in obese mice and reduces lipotoxicity in human islets,” Diabetes, vol. 55, no. 6, pp. 1605–1613, 2006. View at Publisher · View at Google Scholar · View at Scopus
  33. Y.-X. Wang, C.-H. Lee, S. Tiep et al., “Peroxisome-proliferator-activated receptor δ activates fat metabolism to prevent obesity,” Cell, vol. 113, no. 2, pp. 159–170, 2003. View at Publisher · View at Google Scholar · View at Scopus
  34. F. Elhaïmeur, L. Nicod, C. Courderot-Masuyer et al., “Evolution of liver antioxidant status and iron implication during the development of deoxycorticosterone-saline hypertension in rats,” Biological Trace Element Research, vol. 107, no. 3, pp. 263–276, 2005. View at Publisher · View at Google Scholar · View at Scopus
  35. M. Ganz, T. Csak, and G. Szabo, “High fat diet feeding results in gender specific steatohepatitis and inflammasome activation,” World Journal of Gastroenterology, vol. 20, pp. 8525–8534, 2014. View at Google Scholar
  36. B. Fromenty, M. A. Robin, A. Igoudjil, A. Mansouri, and D. Pessayre, “The ins and outs of mitochondrial dysfunction in NASH,” Diabetes and Metabolism, vol. 30, no. 2, pp. 121–138, 2004. View at Publisher · View at Google Scholar · View at Scopus
  37. S. Seki, T. Kitada, T. Yamada, H. Sakaguchi, K. Nakatani, and K. Wakasa, “In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases,” Journal of Hepatology, vol. 37, no. 1, pp. 56–62, 2002. View at Publisher · View at Google Scholar · View at Scopus
  38. A. Aronis, Z. Madar, and O. Tirosh, “Mechanism underlying oxidative stress-mediated lipotoxicity: exposure of J774.2 macrophages to triacylglycerols facilitates mitochondrial reactive oxygen species production and cellular necrosis,” Free Radical Biology and Medicine, vol. 38, no. 9, pp. 1221–1230, 2005. View at Publisher · View at Google Scholar · View at Scopus
  39. A. D. Dobrian, S. D. Schriver, A. A. Khraibi, and R. L. Prewitt, “Pioglitazone prevents hypertension and reduces oxidative stress in diet-induced obesity,” Hypertension, vol. 43, no. 1, pp. 48–56, 2004. View at Publisher · View at Google Scholar · View at Scopus
  40. H. Liu, Z. Jia, S. Soodvilai et al., “Nitro-oleic acid protects the mouse kidney from ischemia and reperfusion injury,” American Journal of Physiology: Renal Physiology, vol. 295, no. 4, pp. F942–F949, 2008. View at Publisher · View at Google Scholar · View at Scopus
  41. M. S. Sana, N. K. Sana, and R. K. Shaha, “Serum lipid profile of hypertensive patients in the northern region of Bangladesh,” Journal of Bioscience and Bioengineering, vol. 14, pp. 93–98, 2006. View at Google Scholar
  42. K. N. Choudhury, A. Mainuddin, M. Wahiduzzaman, and S. M. Islam, “Serum lipid profile and its association with hypertension in Bangladesh,” Journal of Vascular Health and Risk Management, vol. 30, pp. 327–332, 2014. View at Google Scholar