PPAR Research / 2015 / Article / Tab 2

Review Article

Thiazolidinediones and Edema: Recent Advances in the Pathogenesis of Thiazolidinediones-Induced Renal Sodium Retention

Table 2

Different effects of TZDs on ENaC.

Nephron segmentSpeciesMaterialsEffectsCitation

Collecting ductMousePrimary cultured IMCD cellsUpregulation of ENaC-γ mRNA expression [14]
Collecting ductMousePrimary cultured CD cellsIncreased Na transport (suppressed in CD PPAR KO)[15]
CCDMouseSplit-opened isolated CCDChannel activity not altered[16]
CortexMouseKidney cortex lysateDecrease in ENaC-α and -β subunit mRNA expression
Decrease in ENaC-γ subunit protein expression
CCDMouseM1 cell lineDecrease in ENaC-α and -γ subunit mRNA expression[17]
CCDMouseM1 cell line
mpkCCDcl4 cell line
No direct enhancement of Na+ flux via ENaC[18]
KidneyXenopus laevis A6 cell lineNo direct enhancement of Na+ flux via ENaC[18]

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