Review of the Structural and Dynamic Mechanisms of PPARγ Partial Agonism

Figure 3

Crystal structures of indole containing PPARγ partial agonists. (a) Poseview map of SPPARγM2. (b) Crystal structure of SPPARγM2 bound to the PPARγ ligand binding domain. PDB: 2P4Y [50]. (c) Poseview map of MRL24. (d) Crystal structure of MRL24 bound to the PPARγ ligand binding domain. PDB: 2Q5P [47]. (e) Poseview map of nTZDpa. (f) Crystal structure of nTZDpa bound to the PPARγ ligand binding domain. PDB: 2Q5S [47]. The branches of the ligand binding pocket have been labelled with Roman numerals.

(a)

(b)

(c)

(d)

(e)

(f)