Review of the Structural and Dynamic Mechanisms of PPARγ Partial Agonism

Figure 7

Crystal structures of thiazolidine containing PPARγ partial agonists. (a) Poseview map of GW0072. (b) Crystal structure of GW0072 bound to the PPARγ ligand binding domain. PDB: 4PRG [41]. (c) Chemical diagram of GQ-16. (d) Crystal structure of GQ-16 bound to the PPARγ ligand binding domain. PDB: 3T03 [49]. The branches of the ligand binding pocket have been labelled with Roman numerals.

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