Studies on metformin treatment to date in neuroblastoma.
|Reference/s||Year||Study types||Cell lines/animal model ||Effects |
|||2014||In vitro||SKNBE2 and SH-SY5Y cell lines||Significant reduction in the proliferation rate and cell viability, due to inhibition of AKT phosphorylation, and an increased cell death, via apoptosis-independent pathways. |
|||2014||In vivo||SH-SY5Y and SK-N-BE xenograft NB mouse models||Significant inhibition of tumor growth and NB cell viability, interfering with spheroid formation in 3D cultures. Modulation of Rho-GTPases and AMPK activation mediate metformin effects on NB cell survival.|
|||2015||In vitro||SK-N-AS and CHP-212 cell lines||Inhibition of cell proliferation and induction of apoptosis.|
|||2015||In vitro||SH-SY5Y cell line||Reduction of proliferation rate, viability, and invasive potential. |