PPAR Research / 2016 / Article / Tab 2

Review Article

PPAR Gamma in Neuroblastoma: The Translational Perspectives of Hypoglycemic Drugs

Table 2

Studies on metformin treatment to date in neuroblastoma.

Reference/sYearStudy typesCell lines/animal model Effects

[30]2014In vitroSKNBE2 and SH-SY5Y cell linesSignificant reduction in the proliferation rate and cell viability, due to inhibition of AKT phosphorylation, and an increased cell death, via apoptosis-independent pathways.

[31]2014In vivoSH-SY5Y and SK-N-BE xenograft NB mouse modelsSignificant inhibition of tumor growth and NB cell viability, interfering with spheroid formation in 3D cultures. Modulation of Rho-GTPases and AMPK activation mediate metformin effects on NB cell survival.

[32]2015In vitroSK-N-AS and CHP-212 cell linesInhibition of cell proliferation and induction of apoptosis.

[33]2015In vitroSH-SY5Y cell lineReduction of proliferation rate, viability, and invasive potential.

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