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PPAR Research
Volume 2016 (2016), Article ID 3082340, 7 pages
http://dx.doi.org/10.1155/2016/3082340
Review Article

PPARδ as a Metabolic Initiator of Mammary Neoplasia and Immune Tolerance

Department of Oncology, Georgetown University Medical Center and the Lombardi Comprehensive Cancer Center, 3970 Reservoir Rd, NW, Washington, DC 20007, USA

Received 19 July 2016; Accepted 3 November 2016

Academic Editor: Stefano Caruso

Copyright © 2016 Robert I. Glazer. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

PPARδ is a ligand-activated nuclear receptor that regulates the transcription of genes associated with proliferation, metabolism, inflammation, and immunity. Within this transcription factor family, PPARδ is unique in that it initiates oncogenesis in a metabolic and tissue-specific context, especially in mammary epithelium, and can regulate autoimmunity in some tissues. This review discusses its role in these processes and how it ultimately impacts breast cancer.