Pioglitazone Attenuates Drug-Eluting Stent-Induced Proinflammatory State in Patients by Blocking Ubiquitination of PPAR

Figure 3

Pioglitazone blocked the DES-induced PPAR- ubiquitination and degradation in vivo. (a) PPAR- DNA binding activity was shown. (b) PPAR- protein was tested by Western blot. (c) The mRNA expression of PPAR-. (d) The ubiquitination of PPAR- was detected by coimmunoprecipitation assay. , compared with baseline.

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