Pioglitazone Protected against Cardiac Hypertrophy via Inhibiting AKT/GSK3β and MAPK Signaling Pathways

Figure 2

PIO attenuated cardiac fibrosis in vivo. (a) Histological sections of the left ventricle were stained for PSR and average collagen volume in group of AB or sham with or without PIO (). (b) Expression levels of the transcripts for collagen I, collagen III, connective tissue growth factor (CTGF), and fibronectin normalized by GAPDH of the indicated groups by real-time PCR (). as compared with the corresponding sham group. versus the AB group.

(a)

(b)