Potential Role of ANGPTL4 in the Cross Talk between Metabolism and Cancer through PPAR Signaling Pathway

Figure 2

Structural organization and homology between ANGPTL family members. Signal peptide domain is shown in green, specific epitope 1 (SE1) (region present in ANGPTL3 and ANGPTL4 important for binding LPL and inhibiting its activity in vitro and in vivo) in purple red, coiled-coil domain in blue, and N-terminal fibrinogen-like domains in orange. Glycosylation sites (N) are shown at positions 92, 122, 154, 243, and 295 for ANG1; positions 160 and 188 for ANGPTL1; and position 177 for ANGPTL4. Disulfide bonds (SS) are shown at positions 286–315 and 439–452 for ANG1; 280–309 and 432–455 for ANGPTL1; 188–216 and 341–354 for ANGPTL4.