Signaling Mechanisms of Selective PPARγ Modulators in Alzheimer’s Disease

Figure 1

Mechanism of action of PPARγ agonists. (a) During unstimulated conditions, the heterodimer is associated with corepressors which suppress gene transcription. (b) Binding of PPARγ agonist induces release of corepressor complex, while binding to coactivator complex, thereby stimulating the response elements of target genes. This scaffold recruits histone acetyl transferase and RNA polymerase leading to transcription of target genes.

(a)

(b)