To Probe Full and Partial Activation of Human Peroxisome Proliferator-Activated Receptors by Pan-Agonist Chiglitazar Using Molecular Dynamics Simulations

<div>Anisotropic network models of our most abundant cluster of PPARγ (a), our most abundant cluster of PPARγ with nuclear receptor coactivator 2 (NCOA2) peptide docked (b), and the PPARγ-NCOA2 complex from the original crystal structure (PDB ID: 3DZY) (c), plus an RMSF plot (d) comparing the fluctuations of the PPARγ-NCOA2 complex derived from docking NCOA2 into our most abundant cluster of PPARγ (b; blue) to the original crystal structure of the PPARγ-NCOA2 complex (c; red).</div>

PPAR Research

fig15

Figure 15

Figure 15: To Probe Full and Partial Activation of Human Peroxisome Proliferator-Activated Receptors by Pan-Agonist Chiglitazar Using Molecular Dynamics Simulations 

Figure 15 | To Probe Full and Partial Activation of Human Peroxisome Proliferator-Activated Receptors by Pan-Agonist Chiglitazar Using Molecular Dynamics Simulations 