To Probe Full and Partial Activation of Human Peroxisome Proliferator-Activated Receptors by Pan-Agonist Chiglitazar Using Molecular Dynamics Simulations

<div>Structure comparison between the crystal complex and the induced fit docking of chiglitazar to PPAR<i>α</i> with a partial agonist APHM13 (PDB ID: 3VI8), PPAR<i>β</i> with a partial agonist GW0742 (PDB ID: 3TKM), and PPAR<i>γ</i> with a full agonist rosiglitazone (PDB ID: 2PRG). Chiglitazar is shown in green, whereas each crystal ligand is shown in yellow.</div>

PPAR Research

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Figure 3: To Probe Full and Partial Activation of Human Peroxisome Proliferator-Activated Receptors by Pan-Agonist Chiglitazar Using Molecular Dynamics Simulations 

Figure 3 | To Probe Full and Partial Activation of Human Peroxisome Proliferator-Activated Receptors by Pan-Agonist Chiglitazar Using Molecular Dynamics Simulations 