PPARG Drives Molecular Networks as an Inhibitor for the Pathologic Development and Progression of Lung Adenocarcinoma

Figure 2

PPARG-LA regulatory pathways based on literature also tested by using expression data. Entities in blue represent a decreased expression level from the mega-analysis using 13 LA datasets; entities in red represent an increased expression level. Entities highlighted in blue (genes at the bottom of the figure) were literature implicated as an LA-inhibitor; highlighted in red (genes at the top of the figure) means they were LA promoter. The polarity of the relationships was denoted as “-|” for negative effects and “-+>” for positive effects.