Research Article
Pparg may Promote Chemosensitivity of Hypopharyngeal Squamous Cell Carcinoma
Table 1
The top 10 GO terms enriched with the eight genes from the chemosensitivity-promoting pathway.
| | GO ID | Name | # of entities | Overlap | Overlapping entities | value |
| | 0048662 | GO: negative regulation of smooth muscle cell proliferation | 82 | 4 | PPARG; TP53; MIR145; PTEN | 0.00037 | | 0010660 | GO: regulation of muscle cell apoptotic process | 125 | 4 | PPARG; TP53; MIR145; PTEN | 0.0010 | | 0090200 | GO: positive regulation of release of cytochrome c from mitochondria | 33 | 3 | BAX; TNFSF10; TP53 | 0.0014 | | 0030162 | GO: regulation of proteolysis | 997 | 6 | PPARG; BAX; PTEN; SERPINB5; TNFSF10; TP53 | 0.0014 | | 0048147 | GO: negative regulation of fibroblast proliferation | 40 | 3 | BAX; PPARG; TP53 | 0.0020 | | 2001235 | GO: positive regulation of apoptotic signaling pathway | 213 | 4 | BAX; PTEN; TP53; TNFSF10 | 0.0022 | | 0010661 | GO: positive regulation of muscle cell apoptotic process | 48 | 3 | PPARG; TP53; PTEN | 0.0022 | | 0048660 | GO: regulation of smooth muscle cell proliferation | 215 | 4 | PPARG; MIR145; PTEN; TP53 | 0.0022 | | 0090199 | GO: regulation of release of cytochrome c from mitochondria | 53 | 3 | TP53; BAX; TNFSF10 | 0.0024 | | 0090403 | GO: oxidative stress-induced premature senescence | 4 | 2 | TP53; ARNTL | 0.0024 |
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