Role of PPARs in Progression of Anxiety: Literature Analysis and Signaling Pathways Reconstruction

Table 1

List of 14 anxiety-associated proteins–targets of PPARs.

Protein	Full name	Functional class	PPARs
BDNF	Brain derived neurotrophic factor	Growth factor	PPARA; PPARG
CREB1	cAMP responsive element binding protein 1	Class bZIP transcription factor	PPARA; PPARG
CRP	C-reactive protein	Plasma protein	PPARA PPARG
FOS	FOS proto-oncogene, AP-1 transcription factor subunit	Class bZIP transcription factor	PPARA; PPARG
HSD11B2	Hydroxysteroid 11-beta dehydrogenase 2	Steroid metabolism protein	PPARD
IFNG	Interferon gamma	Inflammatory cytokine	PPARA; PPARD; PPARG
IL6	Interleukin 6	Inflammatory cytokine	PPARA; PPARD; PPARG
LEP	Leptin	Adipokine	PPARD; PPARG
NPY	Neuropeptide Y	Neuropeptide	PPARG
NR3C1	Nuclear receptor subfamily 3 group C member 1	Nuclear steroid hormone receptor family	PPARA
PRL	Prolactin	Glycopeptide hormone (gonadotropins)	PPARA
TNF	Tumor necrosis factor	Inflammatory cytokine/adipokine	PPARA; PPARD; PPARG
TSPO	Translocator protein	Mitochondrial damage protein	PPARA
VEGFA	Vascular endothelial growth factor A	Growth factor	PPARA; PPARD; PPARG