Peroxisome Proliferator-Activated Receptors as a Therapeutic Target in Asthma

Table 1

Natural ligands for PPARs.

Ligands	PPARα	PPARβ/δ	PPARγ	Reference
Eicosanoids (PG)	LTB4, 8 (S)-HETE	8 (S)-HETE	8 (S)-HETE, 15-HETE, PGA1, PGA2, PGD2, 15d-PGJ2	[41, 43, 44, 92]
PUFAs, SPM	АА, EPA, LDL, DHA, 17-oxoDHA	АА, EPA, DHA	АА, EPA, DHA, 17-oxoDHA, RvE1, PD1, LXA4	[38, 93, 94]
Endocannabinoids	Anandamide, 2-AG, OEA, PEA	Anandamide	Anandamide, 2-AG, 15D-PGJ2-glycerol ether	[95–99]