Peroxisome Proliferator-Activated Receptors as a Therapeutic Target in Asthma

Table 3

Proresolving lipid mediators and their lung functions.

Mediator		Function	Reference
MaRs	МaR1	Reduces expression of IL-5 and IL-13, decreases lung neutrophils, tissue hypoxia	[117]
Rvs	RvE1	Decreases in airway hyperresponsiveness, regulation of neutrophil chemotaxis, activation of phagocytosis, and synthesis of anti-inflammatory cytokines	[117–121]
	RvD1	Reduces synthesis of proinflammatory mediators and eosinophilia
РDs	РD1	Decreases airway hyperresponsiveness	[116, 122–124]
LXs	LXA4	Slows down chemotaxis and migration to the area of inflammation of macrophages and neutrophils, blocks lipid peroxidation, activates NF-κB, and inhibits the synthesis of proinflammatory cytokines	[117, 125–128]