Pemafibrate Pretreatment Attenuates Apoptosis and Autophagy during Hepatic Ischemia-Reperfusion Injury by Modulating JAK2/STAT3β/PPARα Pathway

Figure 5

PEM modulates the phosphorylation of JAK2/STAT3β in hepatic IRI. (a, b) Protein expression of PPARα, JAK2, STAT3, and p-STAT3. (c) The quantitative analysis of Western blot results of JAK2/STAT3β/PPARα. Data was presented as the (, ^# for Sham versus IRI, for IRI + PEM 0.1 mg/kg versus IRI, ^! for IRI + PEM 0.1 mg/kg versus IRI + PEM 0.5 mg/kg, and ⁺ for IRI + PEM 0.5 mg/kg versus IRI + PEM 1.0 mg/kg; (b) two-way ANOVA; (c) Student’s -test). The expression of PPARα and p-STAT3β was notably increased, but JAK2 saw a steep drop.

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