PPAR Research

PPARs and Xenobiotic-Induced Adverse Effects: Relevance to Human Health


Publishing date
01 Nov 2010
Status
Published
Submission deadline
01 May 2010

Lead Editor

1Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, USA

2Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, USA


PPARs and Xenobiotic-Induced Adverse Effects: Relevance to Human Health

Description

PPAR family members and a number of other nuclear receptors such as CAR, PXR, LXR, RXR, and FXR are transcription factors that play important roles in the regulation of a variety of biological processes, such as adipocyte differentiation, glucose homeostasis, lipid trafficking and metabolism, as well as vascular function and hypertension. Xenobiotic chemicals such as phthalate plasticizers, the synthetic surfactants perfluoroalkyl acids, and a variety of drugs and pesticides have been shown to activate PPAR family members, leading to alterations of cell functions and physiological responses in a number of target organs. The human health risks from chemically induced PPAR activation are presently being debated. This special issue is planned to highlight the recent advances made in (1) identifying chemicals that modulate PPAR activity, (2) characterizing the downstream biochemical and physiological consequences from these chemical insults, as well as (3) addressing the relevance of this action and toxicity for human health risks. We invite authors to present original research articles or reviews that address any aspect of xenobiotic-induced PPAR modulation, and potential related adverse effects to exposed humans. Topics include but are not limited to:

  • Cancer
  • Reproduction
  • Development
  • Immunology
  • Metabolic endpoints
  • Involvement of different PPAR subtypes and RXRs in these effects
  • Clinical and epidemiological studies dealing with this topic with relevance to human health

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/ppar/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2010
  • - Article ID 954639
  • - Editorial

PPARs and Xenobiotic-Induced Adverse Effects: Relevance to Human Health

Christopher Lau | Barbara D. Abbott | ... | Michael L. Cunningham
  • Special Issue
  • - Volume 2010
  • - Article ID 627284
  • - Erratum

Erratum to “Peroxisome Proliferator-Activated Receptors Alpha, Beta, and Gamma mRNA and Protein Expression in Human Fetal Tissues”

Barbara D. Abbott | Carmen R. Wood | ... | Christopher S. Lau
  • Special Issue
  • - Volume 2010
  • - Article ID 727194
  • - Research Article

Regulation of Proteome Maintenance Gene Expression by Activators of Peroxisome Proliferator-Activated Receptor α

Hongzu Ren | Beena Vallanat | ... | J. Christopher Corton
  • Special Issue
  • - Volume 2010
  • - Article ID 325183
  • - Review Article

Gene Expression Changes Induced by PPAR Gamma Agonists in Animal and Human Liver

Alexandra Rogue | Catherine Spire | ... | André Guillouzo
  • Special Issue
  • - Volume 2010
  • - Article ID 681963
  • - Research Article

Effects of the PPAR Agonist and Widely Used Antihyperlipidemic Drug Gemfibrozil on Hepatic Toxicity and Lipid Metabolism

Michael L. Cunningham | Bradley J. Collins | ... | Matthew D. Stout
  • Special Issue
  • - Volume 2010
  • - Article ID 794739
  • - Research Article

Gene Expression Profiling in Wild-Type and PPAR 𝛼 -Null Mice Exposed to Perfluorooctane Sulfonate Reveals PPAR 𝛼 -Independent Effects

Mitchell B. Rosen | Judith R. Schmid | ... | Christopher Lau
  • Special Issue
  • - Volume 2010
  • - Article ID 282896
  • - Research Article

Developmental Effects of Perfluorononanoic Acid in the Mouse Are Dependent on Peroxisome Proliferator-Activated Receptor-Alpha

Cynthia J. Wolf | Robert D. Zehr | ... | Barbara D. Abbott
  • Special Issue
  • - Volume 2010
  • - Article ID 542359
  • - Review Article

The Role of PPAR Activation in Liver and Muscle

Lena Burri | G. Hege Thoresen | Rolf K. Berge
  • Special Issue
  • - Volume 2010
  • - Article ID 584296
  • - Review Article

PPAR in Obesity: Sex Difference and Estrogen Involvement

Michung Yoon
  • Special Issue
  • - Volume 2010
  • - Article ID 690907
  • - Research Article

Peroxisome Proliferator-Activated Receptors Alpha, Beta, and Gamma mRNA and Protein Expression in Human Fetal Tissues

Barbara D. Abbott | Carmen R. Wood | ... | Christopher S. Lau
PPAR Research
 Journal metrics
Acceptance rate44%
Submission to final decision48 days
Acceptance to publication38 days
CiteScore7.100
Impact Factor2.953
 Submit

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.