PPAR Research

The Molecular Basis of PPAR Function


Publishing date
01 Oct 2010
Status
Published
Submission deadline
01 Apr 2010

Lead Editor
Guest Editors

1Magee-Women's research institute, Pittsburgh, PA 15213, USA

2Harvard School of Public Health, Boston, MA 02115, USA


The Molecular Basis of PPAR Function

Description

Over the past three and a half years, thirteen issues of PPAR Research have been published, and an additional six are currently in various phases of production. Collectively, these issues have covered a broad expanse of physiological functions and clinical importance of PPARs. Topics spanned reviews of PPAR function in specific cell and tissue types, their roles in a host of diseases and their rich pharmaceutical potential. Yet, no issue so far has been dedicated to the molecular mechanisms of PPAR action. Clearly, true understanding of the cellular and organismal phenomena regulated by PPARs starts with a detailed grasp on their function as transcription factors. This mechanistic understanding is also a prerequisite for fine-tuning the therapeutic activities of PPARs.

Accordingly, this issue will focus on the molecular mechanisms that underlie the functions of PPARs: their target genes in different tissues and physiological states; transcriptional mechanisms of PPARs and determinants of target gene specificity; interacting partners; structure-function relationships at the molecular and atomic scales; the signaling pathways that regulate PPARs, keeping them in check, boosting, or modifying their activities.

We invite authors to present original research articles or reviews that address any aspect of the molecular basis of PPAR function. Potential topics include but are not limited to:

  • PPAR Target genes: lessons from both in-depth studies of single targets and high-throughput screens
  • Cofactors of PPARs: in vivo and in vitro mechanisms and the basis of differential activity and target specificity
  • Structural insights into PPAR function
  • Posttranslational modifications and their effects on activity and stability of PPARs
  • Regulation of PPAR expression

Before submission, authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/ppar/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2010
  • - Article ID 510530
  • - Editorial

The Molecular Basis of PPAR Function

Yaacov Barak | Chih-Hao Lee
  • Special Issue
  • - Volume 2010
  • - Article ID 679184
  • - Research Article

Coordinate Transcriptomic and Metabolomic Effects of the Insulin Sensitizer Rosiglitazone on Fundamental Metabolic Pathways in Liver, Soleus Muscle, and Adipose Tissue in Diabetic db/db Mice

Sabrina Le Bouter | Marianne Rodriguez | ... | Jean-Pierre Galizzi
  • Special Issue
  • - Volume 2010
  • - Article ID 612089
  • - Research Article

Peroxisome Proliferator-Activated Receptor Alpha Target Genes

Maryam Rakhshandehroo | Bianca Knoch | ... | Sander Kersten
  • Special Issue
  • - Volume 2010
  • - Article ID 409168
  • - Review Article

PPARG: Gene Expression Regulation and Next-Generation Sequencing for Unsolved Issues

Valerio Costa | Maria Assunta Gallo | ... | Alfredo Ciccodicola
  • Special Issue
  • - Volume 2010
  • - Article ID 243643
  • - Review Article

PPARs in Rhythmic Metabolic Regulation and Implications in Health and Disease

Purin Charoensuksai | Wei Xu
  • Special Issue
  • - Volume 2010
  • - Article ID 173907
  • - Research Article

PRIC295, a Nuclear Receptor Coactivator, Identified from PPAR 𝛼 -Interacting Cofactor Complex

Sean R. Pyper | Navin Viswakarma | ... | Janardan K. Reddy
  • Special Issue
  • - Volume 2010
  • - Article ID 169506
  • - Review Article

Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation

Anne Bugge | Susanne Mandrup
  • Special Issue
  • - Volume 2010
  • - Article ID 250126
  • - Review Article

Coactivators in PPAR-Regulated Gene Expression

Navin Viswakarma | Yuzhi Jia | ... | Janardan K. Reddy
  • Special Issue
  • - Volume 2010
  • - Article ID 435689
  • - Review Article

PPARs: Nuclear Receptors Controlled by, and Controlling, Nutrient Handling through Nuclear and Cytosolic Signaling

Maria Moreno | Assunta Lombardi | ... | Pieter de Lange
  • Special Issue
  • - Volume 2010
  • - Article ID 341671
  • - Review Article

PPAR- Signaling Crosstalk in Mesenchymal Stem Cells

Ichiro Takada | Alexander P. Kouzmenko | Shigeaki Kato
PPAR Research
 Journal metrics
Acceptance rate44%
Submission to final decision48 days
Acceptance to publication38 days
CiteScore7.100
Impact Factor2.953
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