Pathology Research International

Research Article

Immunohistochemical Detection of Receptor-Associated Protein in Normal Human Brain and Alzheimer's Disease

Figure 1

RAP immunohistochemistry in normal human cortex and Alzheimer’s disease.
173496.fig.001a
(a) Immunopositive RAP in cortical cells of a normative brain. Note prominent neuronal positivity. High power magnifications show granular neuronal cytoplasmic positivity and areas of dendritic positivity (B, C). Note also positivity in glial cells (arrows, D).
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(b) A representative panel showing positive microvessels (capillaries) with RAP positivity endothelial cells from a normative brain.
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(c) A panel showing the marked reduction in intensity of immunopositivity for RAP in Alzheimer’s disease cortex, note weak staining of cortical neurons and absent staining of microvessels (see arrows).