Effects of the Demethylating Agent, 5-Azacytidine, on Expression of the Kallikrein-Kinin Genes in Carcinoma Cells of the Lung and Pleura

<table>Basal kallikrein-kinin mRNA and protein expression in H2126 lung adenocarcinoma, H520 lung squamous cell carcinoma, and nonmalignant BEAS-2B lung epithelial cells. (a) Fold differences in mRNA expression for the tissue kallikrein (<i>KLK1</i>), plasma kallikrein (<i>KLKB1</i>), kinin B<sub>1</sub> receptor (<i>BDKRB1</i>), kinin B<sub>2</sub> receptor (<i>BDKRB2</i>), and high molecular weight kininogen (<i>KNG1</i>) genes in H2126 cells (white bars) and H520 cells (black bars) relative to that in BEAS-2B cells. (b) Mean cytoplasmic expression of the kallikrein-kinin proteins in BEAS-2B cells (white bars), H2126 cells (hatched bars), and H520 cells (black bars), as assessed by immunofluorescence labelling and image analysis.</table>

Pathology Research International

fig1

Figure 1

Figure 1: Effects of the Demethylating Agent, 5-Azacytidine, on Expression of the Kallikrein-Kinin Genes in Carcinoma Cells of the Lung and Pleura 