Effects of the Demethylating Agent, 5-Azacytidine, on Expression of the Kallikrein-Kinin Genes in Carcinoma Cells of the Lung and Pleura
Figure 5
Schematic map showing putative CpG islands in the KLK1 and KLKB1 genes. (a) The KLK1 gene on chromosome 19q13.3 is 4640 bp in length. It has five exons, five introns, and two potential promoter regions extending ~1000 bases upstream of exon 1 and ~500 bases upstream of exon 5. Mapping indicated a total of six CpG islands in introns 1, 2, 4, and 5, and in exon 5. The most notable is the CpG island in intron 4 which is 50 bp in length and located in a potential promoter region. (b) The KLKB1 gene on chromosome 4q34-35 is 30,954 bp in length. It has 15 exons and 14 introns, with a promoter region extending ~1000 bases upstream of exon 1. Mapping indicated a total of five CpG islands in introns 4, 5, 6, and 11.
