Effects of the Demethylating Agent, 5-Azacytidine, on Expression of the Kallikrein-Kinin Genes in Carcinoma Cells of the Lung and Pleura
Figure 7
Schematic map showing putative CpG islands in the KNG1 gene and a diagram of the KNG1 gene and its two splice variants. (a) The KNG1 gene on chromosome 3q27 is 26,624 bp in length. It has 11 exons and 10 introns with two promoter regions extending ~5000 base pairs upstream of exon 1 and exon 8. A total of five CpG islands were detected in introns 1 and 5. (b) The mRNA splice variants of KNG1 give rise to high molecular weight kininogen (HMWK, H-kininogen) and low molecular weight kininogen (LMWK, L-kininogen) [23].
