236346.fig.004
Figure 4: Distribution of the prion protein ( P r P s c ) deposits with distance across the cortical laminae in the cerebral cortex Creutzfeldt-Jakob disease (CJD). Diffuse deposits in variant CJD (vCJD), fit to polynomial (linear 𝑟 = 0 . 8 2 , 𝑃 < . 0 0 1 ); P r P s c deposits in sporadic (CJD) (sCJD), fit to polynomial (second-order 𝑟 = 0 . 8 1 , 𝑃 < . 0 0 1 ).