Research Article

Role of Apoptosis in Rabies Viral Encephalitis: A Comparative Study in Mice, Canine, and Human Brain with a Review of Literature

Figure 3

Suckling mouse brain infected with CVS strain of rabies virus shows rabies viral antigen within the pyramidal neurons of hippocampus (a). Infected pyramidal neurons (b) and glial cells (c) reveal apoptosis by TUNEL immunolabeling. Endothelial cells lining vessels are negative. Weanling mouse brain infected intramuscularly with CVS strain of rabies virus (d-e) shows rabies viral antigen pyramidal neurons of hippocampus (d) and absence of TUNEL labeling in these neurons (e). Weanling mouse brain infected intramuscularly with street strain of rabies-virus-labeled neurons in hippocampus (f) and TUNEL labeling is negative (g). Brain from adult mouse infected intramuscularly with street and CVS strain of rabies virus, respectively, labeled the neurons (f, h) but no apoptosis seen by TUNEL technique (g, i).
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