Review Article

Molecular Pathology of Hepatic Neoplasms: Classification and Clinical Significance

Figure 2

Patterns of immunohistochemical positivity for CK7 in benign hepatocellular lesions. (a) FNH displays strong CK7 staining of proliferating ductules but virtually no positivity within hepatocytes. (b) An example of HCA (nonmutated, noninflammatory type) showing focal, moderate CK7 staining within hepatocytes as well as heavy staining of a few bile ductules. (c) An I-HCA containing areas of bile ductular proliferation (arrow) with strong CK7 expression, resembling a ductular reaction in FNH, as well as other areas (e.g., bottom of image) in which there is focal hepatocellular staining for CK7, as is typical of HCA.
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