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Pathology Research International
Volume 2011, Article ID 469150, 12 pages
http://dx.doi.org/10.4061/2011/469150
Review Article

A Review of Carcinomas Arising in the Head and Neck Region in HIV-Positive Patients

Department of Pathology, Presbyterian-Shadyside University Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA

Received 14 December 2010; Accepted 14 February 2011

Academic Editor: J. Stebbing

Copyright © 2011 Bibianna Purgina et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. D. Stall, G. L. Greenwood, M. Acree, J. Paul, and T. J. Coates, “Cigarette smoking among gay and bisexual men,” American Journal of Public Health, vol. 89, no. 12, pp. 1875–1878, 1999. View at Google Scholar · View at Scopus
  2. M. M. Marshall, M. C. McCormack, and G. D. Kirk, “Effect of cigarette smoking on HIV acquisition, progression, and mortality,” AIDS Education and Prevention, vol. 21, no. 3, supplement, pp. 28–39, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. S. C. Thompson, C. Nanni, and A. Levine, “The stressors and stress of being HIV-positive,” AIDS Care, vol. 8, no. 1, pp. 5–14, 1996. View at Publisher · View at Google Scholar · View at Scopus
  4. G. M. Clifford, J. Polesel, M. Rickenbach et al., “Cancer risk in the Swiss HIV cohort study: associations with immunodeficiency, smoking, and highly active antiretroviral therapy,” Journal of the National Cancer Institute, vol. 97, no. 6, pp. 425–432, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. American Cancer Society, Cancer Facts & Figures 2010, American Cancer Society, Atlanta, Ga, USA, 2010.
  6. D. Serraino, A. Boschini, P. Carrieri et al., “Cancer risk among men with, or at risk of, HIV infection in southern Europe,” AIDS, vol. 14, no. 5, pp. 553–559, 2000. View at Publisher · View at Google Scholar · View at Scopus
  7. S. M. Mbulaiteye, E. T. Katabira, H. Wabinga et al., “Spectrum of cancers among HIV-infected persons in Africa: the Uganda AIDS-Cancer Registry Match Study,” International Journal of Cancer, vol. 118, no. 4, pp. 985–990, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. Y. Li, M. Law, A. McDonald, P. Correll, J. M. Kaldor, and A. E. Grulich, “Estimation of risk of cancers before occurrence of acquired immunodefi ciency syndrome in persons infected with human immunodefi ciency virus,” American Journal of Epidemiology, vol. 155, no. 2, pp. 153–158, 2002. View at Publisher · View at Google Scholar
  9. M. Frisch, R. J. Biggar, and J. J. Goedert, “Human papillomavirus-associated cancers in patients with human immunodeficiency virus infection and acquired immunodeficiency syndrome,” Journal of the National Cancer Institute, vol. 92, no. 18, pp. 1500–1510, 2000. View at Google Scholar · View at Scopus
  10. A. K. Chaturvedi, M. M. Madeleine, R. J. Biggar, and E. A. Engels, “Risk of human papillomavirus-associated cancers among persons with AIDS,” Journal of the National Cancer Institute, vol. 101, no. 16, pp. 1120–1130, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Newnham, J. Harris, H. S. Evans, B. G. Evans, and H. Møller, “The risk of cancer in HIV-infected people in southeast England: a cohort study,” British Journal of Cancer, vol. 92, no. 1, pp. 194–200, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Guech-Ongey, E. A. Engels, J. J. Goedert, R. J. Biggar, and S. M. Mbulaiteye, “Elevated risk for squamous cell carcinoma of the conjunctiva among adults with AIDS in the United States,” International Journal of Cancer, vol. 122, no. 11, pp. 2590–2593, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. A. E. Grulich, Y. Li, A. McDonald, P. K. L. Correll, M. G. Law, and J. M. Kaldor, “Rates of non-AIDS-defining cancers in people with HIV infection before and after AIDS diagnosis,” AIDS, vol. 16, no. 8, pp. 1155–1161, 2002. View at Publisher · View at Google Scholar · View at Scopus
  14. F. M. Shebl, K. Bhatia, and E. A. Engels, “Salivary gland and nasopharyngeal cancers in individuals with acquired immunodeficiency syndrome in United States,” International Journal of Cancer, vol. 126, no. 10, pp. 2503–2508, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Melbye, T. R. Coté, D. West et al., “Nasopharyngeal carcinoma: an EBV-associated tumour not significantly influenced by HIV-induced immunosuppression,” British Journal of Cancer, vol. 73, no. 8, pp. 995–997, 1996. View at Google Scholar · View at Scopus
  16. T. Powles, J. Powles, M. Nelson et al., “Head and neck cancer in patients with human immunodeficiency virus-1 infection: incidence, outcome and association with Epstein-Barr virus,” Journal of Laryngology and Otology, vol. 118, no. 3, pp. 207–212, 2004. View at Publisher · View at Google Scholar · View at Scopus
  17. G. M. Allardice, D. J. Hole, D. H. Brewster, J. Boyd, and D. J. Goldberg, “Incidence of malignant neoplasms among HIV-infected persons in Scotland,” British Journal of Cancer, vol. 89, no. 3, pp. 505–507, 2003. View at Publisher · View at Google Scholar · View at Scopus
  18. F. M.A. Butt, M. L. Chindia, F. Rana, and F. G. Machigo, “Pattern of head and neck malignant neoplasms in HIV-infected patients in Kenya,” International Journal of Oral and Maxillofacial Surgery, vol. 37, no. 10, pp. 907–911, 2008. View at Publisher · View at Google Scholar
  19. M. Haigentz, “Aerodigestive cancers in HIV infection,” Current Opinion in Oncology, vol. 17, no. 5, pp. 474–478, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. C. M. Flaitz, C. M. Nichols, K. Adler-Storthz, and M. J. Hicks, “Intraoral squamous cell carcinoma in human immunodeficiency virus infection. A clinicopathologic study,” Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and, vol. 80, no. 1, pp. 55–62, 1995. View at Google Scholar · View at Scopus
  21. A. E. Grulich, M. T. van Leeuwen, M. O. Falster, and C. M. Vajdic, “Incidence of cancers in people with HIV/AIDS compared with immunosuppressed transplant recipients: a meta-analysis,” The Lancet, vol. 370, no. 9581, pp. 59–67, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. C. M. Vajdic, S. P. McDonald, M. R.E. McCredie et al., “Cancer incidence before and after kidney transplantation,” Journal of the American Medical Association, vol. 296, no. 23, pp. 2823–2831, 2006. View at Publisher · View at Google Scholar
  23. P. Ammatuna, G. Campisi, L. Giovannelli et al., “Presence of Epstein-Barr virus, cytomegalovirus and human papillomavirus in normal oral mucosa of HIV-infected and renal transplant patients,” Oral Diseases, vol. 7, no. 1, pp. 34–40, 2001. View at Publisher · View at Google Scholar · View at Scopus
  24. A. R. Kreimer, A. J. Alberg, R. Daniel et al., “Oral human papillomavirus infection in adults is associated with sexual behavior and HIV serostatus,” Journal of Infectious Diseases, vol. 189, no. 4, pp. 686–698, 2004. View at Publisher · View at Google Scholar · View at Scopus
  25. H. D. Strickler, R. D. Burk, M. Fazzari et al., “Natural history and possible reactivation of human papillomavirus in human immunodeficiency virus-positive women,” Journal of the National Cancer Institute, vol. 97, no. 8, pp. 577–586, 2005. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Frisch, R. J. Biggar, E. A. Engels, and J. J. Goedert, “Association of cancer with AIDS-related immunosuppression in adults,” Journal of the American Medical Association, vol. 285, no. 13, pp. 1736–1745, 2001. View at Google Scholar · View at Scopus
  27. M. S. McLemore, M. Haigentz, R. V. Smith et al., “Head and neck squamous cell carcinomas in HIV-positive patients: a preliminary investigation of viral associations,” Head and Neck Pathology, vol. 4, no. 2, pp. 97–105, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. A. R. Kreimer, G. M. Clifford, P. Boyle, and S. Franceschi, “Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systemic review,” Cancer Epidemiology Biomarkers and Prevention, vol. 14, no. 2, pp. 467–475, 2005. View at Publisher · View at Google Scholar · View at Scopus
  29. K. K. Ang, J. Harris, R. Wheeler et al., “Human papillomavirus and survival of patients with oropharyngeal cancer,” New England Journal of Medicine, vol. 363, no. 1, pp. 24–35, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. S. Marur, G. D'Souza, W. H. Westra, and A. A. Forastiere, “HPV-associated head and neck cancer: a virus-related cancer epidemic,” The Lancet Oncology, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. W. H. Westra, “The changing face of head and neck cancer in the 21st century: the impact of hpv on the epidemiology and pathology of oral cancer,” Head and Neck Pathology, vol. 3, no. 1, pp. 78–81, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. S. Syrjänen, “Human papillomavirus (HPV) in head and neck cancer,” Journal of Clinical Virology, vol. 32, pp. S59–S66, 2005. View at Publisher · View at Google Scholar · View at Scopus
  33. D. M. Parkin, “The global health burden of infection-associated cancers in the year 2002,” International Journal of Cancer, vol. 118, no. 12, pp. 3030–3044, 2006. View at Publisher · View at Google Scholar · View at Scopus
  34. V. Cogliano, R. Baan, K. Straif, Y. Grosse, B. Secretan, and F. El Ghissassi, “Carcinogenicity of human papillomaviruses,” Lancet Oncology, vol. 6, no. 4, p. 204, 2005. View at Publisher · View at Google Scholar · View at Scopus
  35. R. Herrero, X. Castellsagué, M. Pawlita et al., “The viral etiology of oral cancer: evidence from the IARC multi-centric study,” Journal of the National Cancer Institute. In press.
  36. R. Herrero, X. Castellsagué, M. Pawlita et al., “Human papillomavirus and oral cancer: the international agency for research on cancer multicenter study,” Journal of the National Cancer Institute, vol. 95, no. 23, pp. 1772–1783, 2003. View at Google Scholar · View at Scopus
  37. F. Elamin, H. Steingrimsdottir, S. Wanakulasuriya, N. Johnson, and M. Tavassoli, “Prevalence of human papillomavirus infection in premalignant and malignant lesions of the oral cavity in U.K. subjects: a novel method of detection,” Oral Oncology, vol. 34, no. 3, pp. 191–197, 1998. View at Publisher · View at Google Scholar · View at Scopus
  38. J. B. Epstein, R. J. Cabay, and M. Glick, “Oral malignancies in HIV disease: changes in disease presentation, increasing understanding of molecular pathogenesis, and current management,” Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, vol. 100, no. 5, pp. 571–578, 2005. View at Publisher · View at Google Scholar · View at Scopus
  39. J. B. Epstein, “Oral malignancies associated with HIV,” Journal of the Canadian Dental Association, vol. 73, no. 10, pp. 953–956, 2007. View at Google Scholar · View at Scopus
  40. M. Saqui-Salces, B. Martinez-Benitez, and A. Gamboa-Dominguez, “EBV lymphoepithelial carcinoma of the parotid gland in Mexican mestizo patients with chronic autoimmune diseases,” Pathology and Oncology Research, vol. 12, no. 1, pp. 41–45, 2006. View at Publisher · View at Google Scholar · View at Scopus
  41. H. Feng, M. Shuda, Y. Chang, and P. S. Moore, “Clonal integration of a polyomavirus in human Merkel cell carcinoma,” Science, vol. 319, no. 5866, pp. 1096–1100, 2008. View at Publisher · View at Google Scholar · View at Scopus
  42. H. H. Wong and J. Wang, “Merkel cell carcinoma,” Archives of Pathology and Laboratory Medicine, vol. 134, no. 11, pp. 1711–1716, 2010. View at Google Scholar
  43. J. S. Lewis Jr., E. Duncavage, and P. W. Klonowski, “Oral cavity neuroendocrine carcinoma: a comparison study with cutaneous Merkel cell carcinoma and other mucosal head and neck neuroendocrine carcinomas,” Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, vol. 110, no. 2, pp. 209–217, 2010. View at Publisher · View at Google Scholar
  44. K. D. Mertz, M. Pfaltz, T. Junt et al., “Merkel cell polyomavirus is present in common warts and carcinoma in situ of the skin,” Human Pathology, vol. 41, no. 10, pp. 1369–1379, 2010. View at Publisher · View at Google Scholar
  45. D. M. Reisinger, J. D. Shiffer, A. B. Cognetta, Y. Chang, and P. S. Moore, “Lack of evidence for basal or squamous cell carcinoma infection with Merkel cell polyomavirus in immunocompetent patients with Merkel cell carcinoma,” Journal of the American Academy of Dermatology, 2010. View at Publisher · View at Google Scholar · View at Scopus
  46. L. Barnes, J. W. Eveson, P. W. Reichart, and D. Sidransky, “Tumours of the oral cavity and oropharynx,” in World Health Organization Classification of Tumours: Pathology & Genetics Head and Neck Tumours, chapter 4, pp. 168–175, IARC Press, Lyon, France, 2005. View at Google Scholar
  47. M. Savès, G. Chêne, P. Ducimetière et al., “Risk factors for coronary heart disease in patients treated for human immunodeficiency virus infection compared with the general population,” Clinical Infectious Diseases, vol. 37, no. 2, pp. 292–298, 2003. View at Publisher · View at Google Scholar · View at Scopus
  48. B. Singh, A. N. Balwally, A. R. Shaha, R. M. Rosenfeld, G. Har-El, and F. E. Lucente, “Upper aerodigestive tract squamous cell carcinoma: the human immunodeficiency virus connection,” Archives of Otolaryngology—Head and Neck Surgery, vol. 122, no. 6, pp. 639–643, 1996. View at Google Scholar · View at Scopus
  49. C. Lewden, D. Salmon, P. Morlat et al., “Causes of death among human immunodeficiency virus (HIV)-infected adults in the era of potent antiretroviral therapy: emerging role of hepatitis and cancers, persistent role of AIDS,” International Journal of Epidemiology, vol. 34, no. 1, pp. 121–130, 2005. View at Publisher · View at Google Scholar · View at Scopus
  50. A. E. Grulich, X. Wan, M. G. Law, M. Coates, and J. M. Kaldor, “Risk of cancer in people with AIDS,” AIDS, vol. 13, no. 7, pp. 839–843, 1999. View at Publisher · View at Google Scholar · View at Scopus
  51. W. Tulvatana and S. Tirakunwichcha, “Multifocal squamous cell carcinoma of the conjunctiva with intraocular penetration in a patient with AIDS,” Cornea, vol. 25, no. 6, pp. 745–747, 2006. View at Publisher · View at Google Scholar · View at Scopus
  52. L. Pantanowitz, H. P. Schlecht, and B. J. Dezube, “The growing problem of non-AIDS-defining malignancies in HIV,” Current Opinion in Oncology, vol. 18, no. 5, pp. 469–478, 2006. View at Publisher · View at Google Scholar · View at Scopus
  53. S. K. Chisi, M. K. H. Kollmann, and J. Karimurio, “Conjunctival squamous cell carcinoma in patients with human immunodeficiency virus infection seen at two hospitals in Kenya,” East African Medical Journal, vol. 83, no. 5, pp. 267–270, 2006. View at Google Scholar · View at Scopus
  54. B. Singh, J. F. Carew, and A. R. Shaha, “Laryngeal cancer in patients with acquired immunodeficiency syndrome [1],” American Journal of Clinical Oncology: Cancer Clinical Trials, vol. 21, no. 6, pp. 623–624, 1998. View at Publisher · View at Google Scholar · View at Scopus
  55. S. Shushan, U. Cinamon, D. Levy, M. Sokolov, and Y. Roth, “Laryngeal cancer in acquired immunodeficiency syndrome,” International Journal of STD and AIDS, vol. 20, no. 8, pp. 582–584, 2008. View at Publisher · View at Google Scholar · View at Scopus
  56. B. Singh, S. Sabin, O. Rofim, A. Shaha, G. Har-El, and F. E. Lucente, “Alterations in head and neck cancer occurring in HIV-infected patients—results of a pilot, longitudinal, prospective study,” Acta Oncologica, vol. 38, no. 8, pp. 1047–1050, 1999. View at Google Scholar · View at Scopus
  57. G. D. Kao, P. Devine, and N. Mirza, “Oral cavity and oropharyngeal tumors in human immunodeficiency virus- positive patients: acute response to radiation therapy,” Archives of Otolaryngology—Head and Neck Surgery, vol. 125, no. 8, pp. 873–876, 1999. View at Google Scholar · View at Scopus
  58. M. L. Gillison, “Oropharyngeal cancer: a potential consequence of concomitant HPV and HIV infection,” Current Opinion in Oncology, vol. 21, no. 5, pp. 439–444, 2009. View at Publisher · View at Google Scholar · View at Scopus
  59. P. Appleby, V. Beral, R. Newton, G. Reeves, and L. Carpenter, “Highly active antiretroviral therapy and incidence of cancer in human immunodeficiency virus-infected adults,” Journal of the National Cancer Institute, vol. 92, no. 22, pp. 1823–1830, 2000. View at Google Scholar · View at Scopus
  60. L. Barnes, J. W. Eveson, P. W. Reichart, and D. Sidransky, “Tumours of the salivary glands,” in World Health Organization Classification of Tumours: Pathology & Genetics Head and Neck Tumours, chapter 5, pp. 209–281, IARC Press, Lyon, France, 2005. View at Google Scholar
  61. L. Izikson, E. Nornhold, J. G. Iyer, P. Nghiem, and N. C. Zeitouni, “Merkel cell carcinoma associated with HIV: review of 14 patients,” AIDS, vol. 25, no. 1, pp. 119–121, 2011. View at Publisher · View at Google Scholar
  62. L. Barnes, J. W. Eveson, P. W. Reichart, and D. Sidransky, “Tumours of the nasopharynx,” in World Health Organization Classification of Tumours: Pathology & Genetics Head and Neck Tumours, chapter 2, pp. 83–97, IARC Press, Lyon, France, 2005. View at Google Scholar
  63. M. Poulsen, “Merkel cell carcinoma of skin: diagnosis and management strategies,” Drugs and Aging, vol. 22, no. 3, pp. 219–229, 2005. View at Publisher · View at Google Scholar · View at Scopus
  64. E. A. Engels, M. Frisch, J. J. Goedert, R. J. Biggar, and R. W. Miller, “Merkel cell carcinoma and HIV infection,” The Lancet, vol. 359, no. 9305, pp. 497–498, 2002. View at Publisher · View at Google Scholar · View at Scopus
  65. F. Ottaviani, P. Capaccio, F. Villani et al., “Bona fide primary merkel cell carcinoma of an intraparotid lymph node in a HIV-positive patient,” International Journal of Surgical Pathology, vol. 18, no. 5, pp. 406–408, 2010. View at Publisher · View at Google Scholar
  66. A. A. Andea, R. Patel, S. Ponnazhagan et al., “Merkel cell carcinoma: correlation of KIT expression with survival and evaluation of KIT gene mutational status,” Human Pathology, vol. 41, no. 10, pp. 1405–1412, 2010. View at Publisher · View at Google Scholar · View at Scopus