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Pathology Research International
Volume 2011 (2011), Article ID 480960, 5 pages
Research Article

Molecular Phenotypes of Unifocal, Multifocal, and Diffuse Invasive Breast Carcinomas

1Department of Pathology and Clinical Cytology, Central Hospital Falun, S-791 82 Falun, Sweden
2Center for Clinical Research Dalarna, Uppsala University, Nissers Väg 3, 79181 Falun, Sweden

Received 11 September 2010; Accepted 27 October 2010

Academic Editor: Beiyun Chen

Copyright © 2011 Tibor Tot et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We analyzed the subgross distribution of the invasive component in 875 consecutive cases of breast carcinomas using large-format histology sections and compared the immunophenotype (estrogen and progesterone receptor expression, HER2 overexpression and expression of basal-like markers, CK5/6, CK14, and epidermal growth factor receptor) in unifocal, multifocal, and diffuse tumors. Histology grade and lymph node status were also analyzed. Unifocal invasive carcinomas comprised 58.6% (513/875), multifocal invasive carcinomas 36.5% (319/875), and diffuse invasive carcinomas 4.9% (43/875) of the cases. The proportion of lymph node-positive cases was significantly higher in multifocal and diffuse carcinomas compared to unifocal cancers, but no other statistically significant differences could be verified between these tumor categories. Histological multifocality and diffuse distribution of the invasive tumor component seem to be negative morphologic prognostic parameters in breast carcinomas, independent of the molecular phenotype.