Research Article

Novel Molecular Markers of Malignancy in Histologically Normal and Benign Breast

Table 1

Clinicopathologic summary of IDC, molecularly high-risk and molecularly low-risk, histologically normal breast tissue specimens.

Outside institutionMoffitt Cancer Center (MCC)
Case no.Tiisue core ID (frozen specimens for microarray)Patient age (Years)Side of breast sampledDate of first-tissue diagnosis of BRCASurgical procedure at first-tissue diagnosis of BRCA; INA = Information not availablePathologic diagnosis of BRCADate of surgical procedure at MCCSide of breast sampledSurgical procedureAxillary LN dissection = AX; Sentinel LN dissection, axillary = SLN-AX; Not done = NDFinal pathologic diagnosisHistologic grade (Invasive carcinoma)Tumor size (cm)DCISOther histopathologic findings (resected specimen)

1X41Left2001.04.10Core biopsy IDC, DCIS, high grade, comedo type2005.08.04LeftLumpectomyIntramammary lymph nodesIDC35PresentX
1X41RightXXX2005.08.04RightLumpectomyNDIDC34PresentSkeletal muscle invasion, multifocal
2X38Left2005.07.01Core biopsyIDC2005.08.03LeftModified radical mastectomySLN-AXPapillary CA with a focus of IDC37.5PresentIDC focus 0.8 cm
3X68Right2005.07.20INAIDC2005.08.09RightTotal mastectomySLN-AXIDC32.2PresentX
4X47Left2005.11.28INAIDC2006.01.09LeftMastectomySLN-AXIDC32PresentFocal ductal hyperplasia, radial scar, sclerosing adenosis, microcalcifications
4X47RightXXX2006.01.09RightMastectomySLN-AXFibroadenomatoid hyperplasia, florid ductal hyperplasia, sclerosing adenosis, microcalcificationsNANAAbsentX
5X53Right2006.05.09Core biopsyIDC2006.07.31RightMastectomyAXResidual IDC32.8NSinvolve dermis of skin/nipple
6X71Left2006.04.12Core biopsyDuctal & Lobular CA2006.05.23LeftModified radical mastectomySLN-AXIDC w/lobular features34PresentTumor involves dermal angiolymphatic space in areola
7148061Right2006.05.09INAIDC2006.08.01RightMastectomySLN-AXBenign breastNANAAbsentALH, proliferative fibrocystic changes
7X61LeftXXX2006.08.01LeftMastectomySLN-AXIDC22.6Absent
8148186Right2006.07.31Core biopsyIDC2006.08.29RightTotal mastectomySLN-AXIDC38.5Presentinvolve dermis of skin/nipple
9148252Left2006.02.22Core biopsyIDC2006.03.30LeftTotal mastectomy, skin-sparingSLN-AXIDC21.5PresentX
10148380Left2005.06.13Excisional biopsyMucinous Carcinoma2005.08.16LeftTotal mastectomyNot doneNo residual carcinomaNANAAbsentX
11148442Left2005.07.06Core biopsyDCIS solid type2005.08.15LeftMastectomySLN-AXResidual DCISNA0.4PresentDCIS, multifocal
11X42RightXXX2005.08.15RightMastectomySLN-AXBenign breastNANAAbsentX
12148552Left2006.03.31Core biopsyIDC2006.05.30Left Total mastectomyNDNo residual carcinomaNANAAbsentX
12X52RightXXX2006.05.30RightRt modified radical prophylactic mastectomyAXBenign breastNANAAbsentX
13148667Right2006.05.02Core biopsyDCIS2006.07.12RightMastectomySLN-AXDCISNA1.2PresentX
13X67LeftXXX2006.07.12Leftprophylactic mastectomySLN-AXBenign breastNANAAbsentX
14148767Left2006.06.12Core biopsyDCIS2006.07.31LeftMastectomySLN-AXNo residual DCISNANAAbsent
14X67RightXXX2006.07.31Rightprophylactic mastectomySLN-AXBenign breastNANAAbsentmicrocalcifications
15148849Left2005.05.23Excisional biopsyDCIS2005.08.02LeftTotal MastectomySLN-AXResidual DCISNAXPresentX
16148949Left2005.05.27Excisional biopsy, subareolarAdenoid cystic CA2005.06.14LeftTotal MastectomySLN-AXNo residual carcinomaNANAAbsent ADH
16X49RightXXX2005.06.14Rightprophylactic mastectomySLN-AXBenign breastNANAAbsentX
17149039Right2005.04.26Excisional biopsyDCIS solid type2005.06.29RightMastectomySLN-AXDCIS, multifocalNA2.2PresentX
18149185Left2005.06.30Excisional biopsyIntracystic CA2005.07.28LeftMastectomySLN-AXNo residual carcinomaNANAAbsent ADH
19149247Left2005.11.11Needle-loc excisional biopsyIDC2006.05.02LeftSkin-sparing total mastectomySLN-AXIDC focal micropapillary features32.5PresentX
19X47Right2006.02.27Needle core biopsyFibrocystic changes2006.05.02RightNeedle-loc excisional biopsySLN-AXAdenoma w/adenomyoepitheliomatous features and focal atypiaNANAAbsentSclerosing adenosis, cystic/apocrine changes
20149355Right2006.01.03Cytology: AdenocarcinomaIDC2006.02.20RightMastectomySLN-AXIDC32NSX
20X55LeftXXX2006.02.20LeftMastectomySLN-AXALH; No invasive carcinomaNAXXALH involving lactiferous duct
21149450Right2006.03.15Core biopsyIDC2006.05.22RightBilateral nipple sparing mastectomySLN-AXNo residual carcinomaNANAAbsentX
21X50LeftXXX2006.05.22LeftAs aboveSLN-AXBenign breastNANAAbsentX
22149518RightNANANo clinical evidence of invasive carcinoma2006.06.19Rightprophylactic mastectomy*SLN-AXBenign breastNANAAbsentX
22X18LeftXXX2006.06.19Leftprophylactic mastectomy*SLN-AXBenign breastNANAAbsentX
23149656Right2006.04.04UnknownDCIS2006.06.15RightBilateral mastectomySLN-AXNo residual DCISNANAAbsentDuctal hyperplasia, microcalcifications
23X56LeftXXX2006.06.15LeftBilateral mastectomySLN-AXBenign breastNANAAbsentFat necrosis, microcalcifications
24149748Right2006.06.27LumpectomyIDC, ILC2006.07.28RightModified radical mastectomySLN-AXNo residual invasive carcinoma; LCIS involves nipple ductNANAAbsentX
24X48LeftXXX2006.07.28Leftprophylactic mastectomyNDBenign breastNANAAbsentFocal secretory change

*Strong family history of breast cancer and patient tested positive for BRCA1 gene.