TY - JOUR A2 - Stebbing, J. AU - Purgina, Bibianna AU - Rao, Uma N. M. AU - Miettinen, Markku AU - Pantanowitz, Liron PY - 2011 DA - 2011/03/10 TI - AIDS-Related EBV-Associated Smooth Muscle Tumors: A Review of 64 Published Cases SP - 561548 VL - 2011 AB - The number of reported cases of smooth muscle tumor (SMT) arising in patients with AIDS has been increasing since the mid-1990s. The aim of this study is to characterize the epidemiology, clinical manifestations, pathologic features, prognosis and, management of Epstein-Barr virus-related SMT (EBV-SMT) in patients with AIDS. An English language literature search identified 53 articles including 64 reported cases of EBV-SMT. The majority of these reports involved patients who were young, severely immunosuppressed, and had multifocal tumors. The central nervous system was the most common site to be involved. Histologically, tumors had smooth muscle features and were immunoreactive for muscle markers and all but two tumors demonstrated the presence of EBV by either immunohistochemistry, in situ hybridization, and/or PCR. While mitoses and/or necrosis were used to separate leiomyoma from leiomyosarcoma, these features did not correlate with clinical outcome. Treatment included primarily resection, and less often radiotherapy, chemotherapy and highly active antiretroviral therapy (HAART). Overall, EBV-SMTs appear to have variable aggressiveness and clinical outcome and may exhibit a more favorable prognosis compared to conventional leiomyosarcoma. Tumor-related death from EBV-SMT occurred in only 4 of 51 patients. SN - 2090-8091 UR - https://doi.org/10.4061/2011/561548 DO - 10.4061/2011/561548 JF - Pathology Research International PB - SAGE-Hindawi Access to Research KW - ER -