Human Papillomavirus and Oropharyngeal Squamous Cell Carcinoma: A Case-Control Study regarding Tobacco and Alcohol Consumption

Table 2

HPV and p16^INK4A results of all cases.

Case-case	p16^INK4A overexpression		HPV		Final HPV outcome
		PCR	PCR
		(Amplicor)	(Linear Array)	FISH
1A*	+	Present	HPV-33/52,33,35,58	Absent^§	Positive
1B^†	±	Present	Absent	Absent	Positive
2A	+	Present	Absent	Present	Positive
2B	+	Present	HPV-16	Present	Positive
3A	+	Present	HPV-16	Present	Positive
3B	−	Absent	Absent	Absent	Negative
4A	+	Present	HPV-16	Present	Positive
4B	−	Absent	Absent	Present^||	Negative
5A	+	Present	Absent	Present	Positive
5B	−	Absent	Absent	Absent	Negative
6A	+	Present	HPV-16	Present	Positive
6B	−	Absent	Absent	Absent	Negative
7A	+	Present	HPV-16	Present	Positive
7B	−	Absent	Absent	Absent	Negative
8A	+	Present	HPV-16	Present	Positive
8B	−	Absent	Absent	Absent	Negative
9A	+	NO^‡	NO^‡	Present	Positive
9B	−	Absent	Absent	Absent	Negative
10A	+	Present	NO^‡	NO^‡	Positive
10B	−	Absent	Absent	Absent	Negative
11A	+	Present	NO^‡	Present	Positive
11B	−	Absent	Absent	Absent	Negative
12A	+	NO^‡	NO^‡	Present	Positive
12B	−	NO^‡	NO^‡	Absent	Negative
13A	−	Absent	Absent	Absent	Negative
13B	−	Absent	Absent	Absent	Negative
14A	−	Absent	Absent	Absent	Negative
14B	−	Absent	Absent	Absent	Negative
15A	−	Absent	Absent	Absent	Negative
15B	−	Absent	Absent	Absent	Negative
16A	−	NO^‡	NO^‡	Absent	Negative
16B	+	NO^‡	Absent	Absent	Negative

*A: nonsmoking and nondrinking.
^†B: smoking and drinking.
^‡Not obtained (for PCR tests, for example, due to a negative β-globin PCR).
^§HPV-16-specific FISH probe.
^||poor signal.