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Pathology Research International
Volume 2011 (2011), Article ID 860584, 6 pages
Research Article

Disease Extent ≥4 cm Is a Prognostic Marker of Local Recurrence in T1-2 Breast Cancer

1Department of Pathology and Clinical Cytology, Central Hospital Falun, SE-791 82 Falun, Sweden
2Center for Clinical Research Dalarna, Uppsala University, Nissers väg 3, 791 82 Falun, Sweden

Received 25 April 2011; Revised 8 June 2011; Accepted 13 June 2011

Academic Editor: Gary Tse

Copyright © 2011 D. Lindquist et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Despite improvements of the therapy for breast cancer, a proportion of the patients still get local recurrence. The status of the surgical margins is the most often used parameter for decision regarding additional treatment. However, a negative margin is not a guarantee that there is not residual cancer left in the breast; additional parameters are needed to better predict the risk of local recurrence. The disease extent was evaluated in the surgical specimen from 313 women after breast-conserving therapy using large-section histology and was correlated to the incidence of local recurrence. A disease extent ≥4 cm was shown to be an independent marker for local recurrence; the cumulative 10-year local relapse rate for the group with a disease extent ≥4 cm was 20.5%, and for the rest 6.7%. We conclude that disease extent ≥4 cm seems to be an important factor when evaluating the risk for local recurrence.