Histopathological Evaluation of Behçet's Disease and Identification of New Skin Lesions

Table 2

An overview of the reported histopathological and immunoflourescence features of Behçet’s disease common mucocutaneous lesions.

Mucocutaneous lesions	Reported histopathological features
Recurrent oral Aphthae	Lymphocytes, macrophages, neutrophils at the base of the ulcer, sometimes penetrating epidermis at the periphery
	Similar infiltrate at the perivascular regions in dermis fibrinoid necrosis of vessel walls (rare)
	Also granular IgM and C3 deposits in dermoepidermal junction and in perivascular regions (in RAS, no deposits of immunoreactants) [30]
Genital ulceration	Similar histopathological features to oral aphthae
Erythema-nodosum-like lesions	Neutrophilic vasculitis
	Lymphocytic vasculitis
	Necrobiosis
	IgM deposits at the vessel walls [40]
Pathergy reaction	Perivascular infiltrate of mononuclear cells
	Vasculitis (neutrophilic, leukocytokclastic) (+/−)
	Presence of mast Cells.
	IgM, IgA, and C3 deposits
Papulopustular lesions	Intraepidermal pustules, spongiosis, neutrophil/lymphocyte exocytosis, and basal keratinocyte vacuolization,
	Edema in dermis, lymphohistiocytic/neutrophilic inflammatory infiltration between collagen fibers, and perivascular areas
	Vasculitis (+/−)
Thrombophlebitis	Thrombi in the vessel lumen
	Perivascular infiltrate of mononuclear cells