Fibroblast Growth Factor Receptor 2: Expression, Roles, and Potential As a Novel Molecular Target for Colorectal Cancer

Table 2

Roles of FGFR2 and its splicing variants in colorectal cancers.

		Reported data	Roles
FGFR2	normal	located in the upper portion of the intestinal crypt [50, 54]	differentiation, growth
	cancer	increased expression in the invasive front of cancer cells	invasion, growth
		shRNA-targeting FGFR2 suppressed cell growth [53]
FGFR2 IIIb	normal	located in the upper portion of the intestinal crypt [50]	differentiation, growth
	cancer	Well-differentiated types [50]	differentiation
	cancer	FGF-7 induced an increase of VEGF-A [56]	angiogenesis
	cancer	FGF7 enhanced the adhesion to type-IV collagen [57]	cell attachment
	cancer	FGF10 increased the growth rate [51]	growth
FGFR2 IIIc	cancer	expressed in cancer cells (the present report)	not reported