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Pathology Research International
Volume 2012, Article ID 851432, 8 pages
http://dx.doi.org/10.1155/2012/851432
Clinical Study

Immunohistochemical Expression of Platelet-Derived Growth Factor Receptors in Ovarian Cancer Patients with Long-Term Follow-Up

1Department of Oncology, Vejle Hospital, Kabbeltoft 25, 7100 Vejle, Denmark
2Institute for Regional Health Services Research, University of Southern Denmark, 5230 Odense, Denmark
3Department of Pathology, Vejle Hospital, Kabbeltoft 25, 7100 Vejle, Denmark

Received 28 June 2012; Revised 28 August 2012; Accepted 28 August 2012

Academic Editor: Paulette Mhawech-Fauceglia

Copyright © 2012 Christine Vestergaard Madsen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. The well-documented role of the PDGF system in tumor growth and angiogenesis has prompted the development of new biological agents targeting the PDGF system. The aim of the present study was to analyze the expression of the PDGF-receptors in ovarian cancer and to investigate its relation to histopathological parameters and long-term overall survival. Methods. The immunohistochemical expression of PDGFR-α and PDGFR-β was investigated in tumor and stromal cells in 170 patients with histologically verified epithelial ovarian cancer. Results. Almost half of the tumor specimens showed high expression of PDGFR-α and PDGFR-β in tumor cells (43% and 41%) and in stromal compartments (32% and 44%). There was a significant association between high expression of PDGFR-α and high expression of PDGFR-β in both tumor and stromal cells. Coexpression of PDGFR-α and PDGFR-β in stromal cells was seen more often in serous adenocarcinomas than in nonserous adenocarcinomas. No clear correlation between PDGFR expression and longterm overall survival or clinical parameters was found. Conclusions. PDGFR-α and PDGFR-β were expressed in a subset of ovarian carcinomas but did not show significant prognostic importance in this material.