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Pathology Research International
Volume 2012, Article ID 908106, 7 pages
http://dx.doi.org/10.1155/2012/908106
Clinical Study

Role of Multiparameter Analysis of AgNORs in FNA Smears of Thyroid Swellings in Differentiating Benign and Malignant Lesions

1Department of Pathology, Chittagong Medical College, Chittagong 4203, Bangladesh
2Department of Pathology, Cox's Bazar Medical College, Cox's Bazar 4700, Bangladesh

Received 14 February 2012; Revised 18 April 2012; Accepted 2 May 2012

Academic Editor: Luigi Terracciano

Copyright © 2012 Mohammad Ismail Hossain et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. K. Young, O. G. Lumapas, and R. Mirasol, “Sonography guided fine-needle aspiration biopsy of thyroid nodules: correlation between cytologic and histopathologic findings,” Phillipine Journal of Internal Medicine, vol. 49, no. 1, pp. 8–14, 2011. View at Google Scholar
  2. R. Basharat, M. H. Bukhari, S. Saeed, and T. Hamid, “Comparison of fine needle aspiration cytology and thyroid scan in solitary thyroid nodule,” Pathology Research International, vol. 2011, Article ID 754041, 9 pages, 2011. View at Google Scholar
  3. A. Sengupta, R. Pal, S. Kar, F. A. Zaman, S. Sengupta, and S. Pal, “Fine needle aspiration cytology as the primary diagnostic tool in thyroid enlargement,” Journal of Natural Science, Biology and Medicine, vol. 2, no. 1, pp. 113–118, 2011. View at Google Scholar
  4. S. Asotra and J. Sharma, “Role of AgNORs in thyroid lesions on fine needle aspiration cytology smears,” Journal of Cytology, vol. 25, no. 1, pp. 18–22, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. D. Ciobanu, I. D. Cǎruntu, C. Vulpoi, N. Florea, and S. E. Giuşcǎ, “Morphometric parameters and silver stain used in diagnosis of thyroid follicular diseases,” Romanian Journal of Morphology and Embryology, vol. 47, no. 4, pp. 323–330, 2006. View at Google Scholar · View at Scopus
  6. A. Augustynowicz, J. Dziecioł, M. Barwijuk-Machała, J. Dadan, Z. Puchalski, and S. Sulkowski, “Assessment of proliferative activity of thyroid Hürthle cell tumors using PCNA, Ki-67 and AgNOR methods,” Folia Histochemica et Cytobiologica, vol. 42, no. 3, pp. 165–168, 2004. View at Google Scholar · View at Scopus
  7. M. H. Bukhari, S. Niazi, S. A. Khan et al., “Modified method of AgNOR staining for tissue and interpretation in histopathology,” International Journal of Experimental Pathology, vol. 88, no. 1, pp. 47–53, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. B. M. Biswal and N. H. Othman, “Correlation of nuclear morphometry and AgNOR score with radiation response in squamous cell cancers of the head and neck: a preliminary study,” Malaysian Journal of Medical Sciences, vol. 17, no. 3, pp. 19–26, 2010. View at Google Scholar · View at Scopus
  9. S. Mukhopadhyay, “Quantitative estimation of AgNORs in inflammatory gingival overgrowth in pediatric patients and its correlation with the dental plaque status,” Journal of Indian Society of Pedodontics and Preventive Dentistry, vol. 27, no. 4, pp. 235–241, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. G. F. Dumitrescu, “Diagnostic value of silver nitrate staining for nucleolar organizer regions in cerebral astrocytic tumors,” Romanian neurosurgery, vol. 17, no. 1, pp. 64–72, 2010. View at Google Scholar
  11. L. D. C. Hildebrand, V. C. Carrard, I. D. S. Lauxen, O. F. De Quadros, A. C. M. Chaves, and M. Sant'Ana-Filho, “Evaluation of cell proliferation rate in non-dysplastic leukoplakias,” Medicina Oral, Patología Oral y Cirugía Bucal, vol. 15, no. 2, pp. e328–e334, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. H. Ansari, G. Mehdi, V. Maheshwari, and S. Siddiqui, “Evaluation of AgNOR scores in aspiration cytology smears of breast tumors,” Journal of Cytology, vol. 25, no. 3, pp. 100–104, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. W. A. Mourad, S. Devloo, and S. Setrakian, “Predictors of invasion in ductal carcinoma in situ of the breast: the value of a scoring system,” Annals of Saudi Medicine, vol. 17, no. 4, pp. 427–431, 1997. View at Google Scholar · View at Scopus
  14. A. Mehrotra, P. K. Agarwal, and T. Chandra, “Cytopathology and AgNOR counts in fine needle aspiration cytology smears of thyroid lesions,” Diagnostic Cytopathology, vol. 19, pp. 238–243, 1998. View at Google Scholar
  15. M. H. Bukhari, S. Niazi, I. Hashmi et al., “Use of AgNOR index in grading and differential diagnosis of astrocytic lesions of brain,” Pakistan Journal of Medical Sciences, vol. 23, no. 2, pp. 206–210, 2007. View at Google Scholar · View at Scopus
  16. T. Elangovan, N. Mani, and N. Malathi, “Argyrophilic nucleolar organizer regions in inflammatory, premalignant, and malignant oral lesions: a quantitative and qualitative assessment,” Indian Journal of Dental Research, vol. 19, no. 2, pp. 141–146, 2008. View at Google Scholar · View at Scopus
  17. “Interphase nucleolar organizer regions in tumour pathology,” in Molecular Biology in Cellular Pathology, J. Crocker and P. G. Murray, Eds., pp. 144–145, John Wiley & Sons, London, UK, 2nd edition, 2003.
  18. F. Lumachi, M. Ermani, F. Marino et al., “Relationship of AgNOR counts and nuclear DNA content to survival in patients with parathyroid carcinoma,” Endocrine-Related Cancer, vol. 11, no. 3, pp. 563–569, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. A. H. Khan, S. A. Khan, N. A. Chaudhry, and M. Tayyab, “Comparison of argyrophilic nucleolar organizer regions (AgNORs) with proliferating cell nucleolar antigen (PCNA) in different grades of transitional cell carcinoma of urinary bladder,” Annals, vol. 13, no. 2, pp. 186–190, 2007. View at Google Scholar
  20. H. Gharib and J. R. Goellner, “Fine-needle aspiration biopsy of the thyroid: an appraisal,” Annals of Internal Medicine, vol. 118, no. 4, pp. 282–289, 1993. View at Google Scholar · View at Scopus
  21. F. I. Wahid, S. F. Khan, H. U. Rehman, and I. A. Khan, “Role of fine needle aspiration cytology in diagnosis of solitary thyroid nodules,” Iranian Journal of Otorhinolaryngology, vol. 23, no. 4, pp. 111–118, 2011. View at Google Scholar
  22. T. Solymosi, V. Toth, Z. Sapi, M. Bodo, I. Gal, and L. Csanadi, “Diagnostic value of AgNOR: method in thyroid cytopathology: correlation with morphometric measurements,” Diagnostic Cytopathology, vol. 14, no. 2, pp. 140–144, 1996. View at Google Scholar
  23. D. Slowińska-Klencka, M. Klencki, B. Popowicz, S. Sporny, and A. Lewiński, “Multiparameter analysis of AgNOR in thyroid lesions: comparison with PCNA expression,” Histology and Histopathology, vol. 19, no. 3, pp. 785–792, 2004. View at Google Scholar · View at Scopus
  24. H. B. Burch, K. D. Burman, H. L. Reed, L. Buckner, T. Raber, and J. L. Ownbey, “Fine needle aspiration of thyroid nodules: determinants of insufficiency rate and malignancy yield at thyroidectomy,” Acta Cytologica, vol. 40, no. 6, pp. 1176–1183, 1996. View at Google Scholar · View at Scopus
  25. N. Leonard and D. H. Melcher, “To operate or not to operate? The value of fine needle aspiration cytology in the assessment of thyroid swellings,” Journal of Clinical Pathology, vol. 50, no. 11, pp. 941–943, 1997. View at Google Scholar · View at Scopus
  26. T. W. Khanzada, A. Samad, B. Kumar, and W. Memon, “The diagnostic value of fine needle aspiration cytology in thyroid nodules,” Pakistan Journal of Otolaryngology, vol. 25, pp. 39–41, 2009. View at Google Scholar
  27. J. B. Lingegowda, P. H. Muddegowda, R. N. Kumar, and R. R. Kurpad, “Application of pattern analysis in fine needle aspiration of solitary nodule of thyroid,” Journal of Cytology, vol. 27, no. 1, pp. 1–7, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. J. H. Chern, Y. C. Lee, M. H. Yang, S. C. Chang, and R. P. Perng, “Usefulness of argyrophilic nucleolar organizer regions score to differentiate suspicious malignancy in pulmonary cytology,” Chest, vol. 111, no. 6, pp. 1591–1596, 1997. View at Google Scholar · View at Scopus
  29. Palaoro La, A. S. Rocher, J. Rofrano, S. M. Curi, and V. Penzutti, “Utility of AgNOR, Immunocytochemistry for CEA and tumour markers for diagnosis in serous fluids,” Revista Brasileria de Cancerologica, vol. 54, no. 4, pp. 317–327, 2008. View at Google Scholar