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Pathology Research International
Volume 2013 (2013), Article ID 782395, 18 pages
http://dx.doi.org/10.1155/2013/782395
Review Article

A Compendium of Urinary Biomarkers Indicative of Glomerular Podocytopathy

1Department of Laboratory Medicine and Pathology, University of Minnesota, 420 Delaware Street SE, MMC 609 Mayo D185, Minneapolis, MN 55455, USA
2Division of Nephrology, Department of Medicine, Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Boston, MA 02129, USA
3University of Belgrade School of Medicine, Dr. Subotica 8, 11000 Belgrade, Serbia

Received 22 July 2013; Accepted 10 September 2013

Academic Editor: Piero Tosi

Copyright © 2013 Miroslav Sekulic and Simona Pichler Sekulic. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

It is well known that glomerular podocyte injury and loss are present in numerous nephropathies and that the pathophysiologic consecution of disease hinges upon the fate of the podocyte. While multiple factors play a hand in glomerulopathy progression, basic logic lends that if one monitors the podocyte’s status, that may reflect the status of disease. Recent investigations have focused on what one can elucidate from the noninvasive collection of urine, and have proven that certain, specific biomarkers of podocytes can be readily identified via varying techniques. This paper has brought together all described urinary biomarkers of podocyte injury and is made to provide a concise summary of their utility and testing in laboratory and clinical theatres. While promising in the potential that they hold as tools for clinicians and investigators, the described biomarkers require further comprehensive vetting in the form of larger clinical trials and studies that would give their value true weight. These urinary biomarkers are put forth as novel indicators of glomerular disease presence, disease progression, and therapeutic efficacy that in some cases may be more advantageous than the established parameters/measures currently used in practice.