Pathological and Immunological Developments in Behcet’s Disease
1Department of Dermatology, University of Mersin School of Medicine, Mersin, 33079, Turkey
2Dermatologie Afdelingen, Bovenij Ziekenhuis, Postbus 37610, 1030 BD Amsterdam, The Netherlands
3Department of Dermatology, University of Florence, Via della Pergola 60, 50132 Florence, Italy
4Rheumatology Research Center, Shariati Hospital, Kargar Avenue, Tehran, Iran
Pathological and Immunological Developments in Behcet’s Disease
Description
Behcet disease is a rare form of vasculitis that may have systemic multiorgan involvement. Behçet's disease was first defined by Hulusi Behçet, a Turkish Professor of dermatology, in 1937 as a triad of recurrent aphthous stomatitis, genital aphthae, and relapsing uveitis. As this disease can be fatal, an immediate medical treatment is mandatory. So far there is no specific pathological testing or technique available for the diagnosis of the disease, although the International Study Group criteria for the disease are of good sensitivity and specificity. However, quite a portion of patients are misdiagnosed or have been delayed diagnosis. During the ensuing 65 years, multiple systemic associations of the disease including articular, vascular, gastrointestinal, cardiopulmonary, and neurologic involvement have become increasingly apparent. Although the etiology and pathogenesis is not clearly defined, genetic predisposition, infections, and immunological dysfunctions have been implicated. Behcet's disease has been reported worldwide, but has a distinct geographic distribution, with highest prevalences in countries along the ancient silk route. Although much has been learned during recent years on the pathogenesis and treatment of the disease, it is still an important cause of morbidity and mortality in areas where it is prevalent. Potential topics include, but are not limited to:
- Development and testing relevant investigations on Behcet's disease
- Genetic susceptibilities of Behçet's disease
- Development of immunopathogenesis strategies to treat Behcet's disease
- Elucidating the role of stress factors and stress hormones in the development of Behcet's disease
- Identification of new different skin lesions and histopathological results in Behcet's disease
- New diagnostic criteria in Behcet's disease (diagnostic/classification criteria for Behcet's disease)
- New animal models to test and understand immunopathogenesis of Behcet's disease
- New evidence-based treatment approach in Behcet's disease
- Osteoporosis and rare musculosceletal findings in Behçet's disease
- Clinical and pathological manifestations with differential diagnosis in Behçet's disease
- Pathologic features of Behcet's disease in the tubular gut
- Diagnostic/Classification criteria for Behcet's Disease
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