Effect of N-Methyl-D-Aspartate Receptor Antagonist Dextromethorphan on Opioid Analgesia in Pediatric Intensive Care Unit

Table 1

Demographic characteristics. Clinical Outcomes of subjects in Groups 1 and 2 in RCT. Kolmogorov-Smirnov test used to assess distribution. nc, not computed.

Characteristics	Group 1: dextromethorphan (number = 16)	Group 2: placebo (number = 13)	value
	Median (IQR)	Median (IQR)
Age (Yr.)	9.7 (8–12)	5.54 (3.5–6)	0.0015
Gender: Male (number)	9	10	nc
LOS-PICU (days)	9 (6–21)	12 (6–24)	0.431
LOS-Hospital (days)	16.5 (9–46)	24.5 (12–61.5)	0.501
PRISM	17 (15–21)	18.1 (15.5–22)	0.75
Intubated (number)	16	13	nc
Underlying diagnosis (number)
Trauma	10	10	0.57
Hem/onco	3	0	NA
Post-op	2	1	0.672
Respiratory failure	1	1	0.879
Burn	0	1	NA
Fentanyl infusion-start µ/kg/hr	2 (1–4)	2 (1–3)	0.16
Fentanyl infusion-end µ/kg/hr	3 (2–4)	3 (1–4)	0.7
Midazolam infusion-start mg/kg/hr	0.09	0.11	0.36
Midazolam infusion-end mg/kg/hr	0.16	0.18	0.27