Pain Research and Management / 2016 / Article / Tab 2 / Clinical Study
Effect of N-Methyl-D-Aspartate Receptor Antagonist Dextromethorphan on Opioid Analgesia in Pediatric Intensive Care Unit Table 2 Biochemical variables of subjects in groups 1 and 2 in RCT. Groups compared via Student’s
t -test comparison of means.
is significant. Values are expressed as mean and standard deviation.
Group 1: dextromethorphan (number: 16) Group 2: placebo (number: 13) p Mean SDMean SDWBC (×103 /mm3 ) Start 12.81 6.337 14.92 5.937 0.673 End 11.13 3.879 11.31 3.225 0.894 Hemoglobin (g/L) Start 103.56 16.252 112.23 12.544 0.104 End 97.81 12.079 101.92 12.493 0.3747 Platelets (×103 /mm) Start 302.31 169.591 362.54 166.289 0.348 End 287.06 138.546 352.00 144.741 0.228 Aspartate transaminase (AST) (units/L) Start 44.25 14.040 42.23 12.357 0.687 End 57.80 32.182 52.60 13.390 0.747 Alanine transaminase (ALT) (units/L) Start 46.80 11.351 42.13 12.426 0.404 End 48.80 18.431 45.33 21.068 0.777 Prothrombin time (seconds) Start 10.29 1.816 9.77 1.964 0.419 End 11.63 1.598 10.90 1.969 0.433 International normalized ratio Start 1.00 0.000 1.08 0.277 0.289 End 1.00 0.000 1.00 0.000 1 Activated partial thromboplastin time (seconds) Start 27.29 5.525 27.08 5.795 0.918 End 26.38 4.104 29.10 6.226 0.302 Serum sodium (mmol/L) Start 138.81 4.969 139.77 3.632 0.591 End 140.94 6.698 142.38 5.268 0.545 Serum potassium (mmol/L) Start 3.88 0.500 3.85 0.555 0.879 End 3.94 0.574 3.69 0.630 0.377 Serum chloride (mmol/L) Start 110.50 7.294 106.77 6.126 0.157 End 107.75 8.560 106.46 4.630 0.651 CO2 (mmol/L) Start 20.36 4.396 19.36 7.953 0.693 End 25.00 3.211 25.73 3.901 0.611 Blood glucose (mmol/L) Start 6.67 1.676 8.58 4.100 0.18 End 6.73 1.870 6.90 3.178 0.868 Blood urea nitrogen (mmol/L) Start 2.50 1.211 3.54 1.391 0.048 End 2.63 1.962 1.69 0.751 0.12 Serum creatinine (µ mol/L) Start 32.25 11.947 37.15 7.069 0.208 End 30.00 14.367 36.38 10.524 0.193