Clinical Study

Effect of N-Methyl-D-Aspartate Receptor Antagonist Dextromethorphan on Opioid Analgesia in Pediatric Intensive Care Unit

Table 2

Biochemical variables of subjects in groups 1 and 2 in RCT. Groups compared via Student’s t-test comparison of means. is significant. Values are expressed as mean and standard deviation.

Group 1: dextromethorphan (number: 16)Group 2: placebo (number: 13)p  
MeanSDMeanSD

WBC (×103/mm3)Start12.816.33714.925.9370.673
End11.133.87911.313.2250.894
Hemoglobin (g/L)Start103.5616.252112.2312.5440.104
End97.8112.079101.9212.4930.3747
Platelets (×103/mm)Start302.31169.591362.54166.2890.348
End287.06138.546352.00144.7410.228
Aspartate transaminase (AST) (units/L)Start44.2514.04042.2312.3570.687
End57.8032.18252.6013.3900.747
Alanine transaminase (ALT) (units/L)Start46.8011.35142.1312.4260.404
End48.8018.43145.3321.0680.777
Prothrombin time (seconds)Start10.291.8169.771.9640.419
End11.631.59810.901.9690.433
International normalized ratioStart1.000.0001.080.2770.289
End1.000.0001.000.0001
Activated partial thromboplastin time (seconds)Start27.295.52527.085.7950.918
End26.384.10429.106.2260.302
Serum sodium (mmol/L)Start138.814.969139.773.6320.591
End140.946.698142.385.2680.545
Serum potassium (mmol/L)Start3.88 0.5003.850.5550.879
End3.940.5743.690.6300.377
Serum chloride (mmol/L)Start110.507.294106.776.1260.157
End107.758.560106.464.6300.651
CO2 (mmol/L)Start20.364.39619.367.9530.693
End25.003.21125.733.9010.611
Blood glucose (mmol/L)Start6.671.6768.584.1000.18
End6.731.8706.903.1780.868
Blood urea nitrogen (mmol/L)Start2.501.2113.541.3910.048
End2.631.9621.690.7510.12
Serum creatinine (µmol/L)Start32.2511.94737.157.0690.208
End30.0014.36736.3810.5240.193