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Pain Research and Management
Volume 2016 (2016), Article ID 3689352, 6 pages
Research Article

The Effect of Guidance regarding Home Exercise and ADL on Adolescent Females Suffering from Adverse Effects after HPV Vaccination in Japanese Multidisciplinary Pain Centers

1Multidisciplinary Pain Centre, School of Medicine, Aichi Medical University, Aichi 480-1195, Japan
2Department of Pain Medicine, Osaka University, Graduate School of Medicine, Japan
3Pain Clinic, The Jikei University Hospital, Japan
4Department of Orthopedic Surgery, Fukushima Medical University School of Medicine, Japan
5Department of Pain and Palliative Medicine, The University of Tokyo Hospital, Japan
6Department of Rehabilitation Medicine, Sapporo Medical University, Japan
7Department of Anesthesiology and Pain Management, Juntendo University School of Medicine, Japan
8Department of Psychosomatic Medicine, Kyushu University Hospital, Japan
9Department of Anesthesiology & Critical Care Medicine, Kyushu University Hospital, Japan
10Department of Orthopedic Surgery, Okayama University Hospital, Japan
11Department of Anesthesiology and Resuscitology, Okayama University Hospital, Japan
12Interdisciplinary Pain Management Center, Shiga University of Medical Science Hospital, Japan
13Department of Orthopedic Surgery, Kochi Medical School, Japan

Received 2 February 2015; Accepted 14 August 2015

Copyright © 2016 Takahiro Ushida et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Two prophylactic papillomavirus (HPV) vaccines have been available for primary prevention of cervical cancer. Although serious adverse effects (AE) were rare, more than 230 women have been suffering from severe AEs such as persistent pain and headache in Japan. Our research group started to treat adolescent females suffering from the AEs. Objective. To survey the characteristics of and the effects of cognitive behavioral therapy on adolescent female suffering from the AEs in Japanese multidisciplinary pain centers. Methods. One hundred and forty-five patients suffering from the AEs were reviewed retrospectively and 105 patients of them were provided guidance on home exercise and activities of daily living based partially on a cognitive-behavioral approach. The intensity of pain was rated by the patients using a numerical rating scale (NRS). Furthermore, the Hospital Anxiety and Depression Scale (HADS) and the Pain Catastrophizing Scale (PCS) were used. Results. Eighty out of the 105 patients who received the guidance were followed up, 10 displayed a marked improvement, and 43 showed some improvement. Conclusions. Guidance on home exercise and activities of daily living based on a cognitive-behavioral approach alleviated the AEs that women suffered from after HPV vaccination in Japan.