Pain Research and Management / 2017 / Article / Tab 4

Clinical Study

Efficacy and Safety of Transdermal Buprenorphine versus Oral Tramadol/Acetaminophen in Patients with Persistent Postoperative Pain after Spinal Surgery

Table 4

Medication compliance rate, dose change, and use of rescue medication.

Full analysis set Buprenorphine transdermal system
Oral tramadol/acetaminophen

Medication compliance rate, %, mean ± SD
 At Week 297.9 ± 10.192.5 ± 21.10.0078
 At Week 697.8 ± 14.191.0 ± 18.9<0.0001
Dose change of study medication
 Patients requiring dose change during study, (%)9 (15.8)8 (15.7)
 Week 6 dose of patients who had dose change10 μg/h2 tablets
 Dose change, mean ± SD0.79 ± 1.84 μg0.16 ± 0.37 tablets
Total dose of rescue medication, mg, mean ± SD
 Baseline to week 2 (2-week duration)1,439.2 ± 1,741.31,412.2 ± 2,009.70.9429
 Week 2 to week 6 (4-week duration)1,534.7 ± 1,820.01,869.4 ± 2,530.00.4542

Medication compliance rate = total number of doses actually administered (actual number of medication days)/total number of doses prescribed (number of medication days prescribed); rank sum test; -test.

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