Pain Research and Management / 2018 / Article / Tab 5

Review Article

Targeting the Endocannabinoid System for Prevention or Treatment of Chemotherapy-Induced Neuropathic Pain: Studies in Animal Models

Table 5

Effects of other agents, in a CB receptor-dependent manner, in animal models of CINP.

CINP modelMoleculeEffectsEffects of CB receptor antagonists on the activity of the compoundReference
Chemotherapy drugAnimal

PaclitaxelFemale and male BALB/c miceIndomethacin (NSAID) plus minocycline (semisynthetic tetracycline antibiotic)Reduced established thermal hyperalgesiaCB1 antagonist AM251 antagonised[53]
PaclitaxelMale Sprague-Dawley ratsDesipramine (tricyclic antidepressant)Prevented the development of mechanical and cold allodyniaCB1 antagonist AM251 and CB2 antagonist AM630 partially antagonised[52]

NSAID, nonsteroidal anti-inflammatory drug.