Pain Research and Management / 2018 / Article / Tab 1

Research Article

Antinociceptive Activity of Methanolic Extract of Clinacanthus nutans Leaves: Possible Mechanisms of Action Involved

Table 1

Several flavonoid-based bioactive compounds with antinociceptive potential that has been previously identified from MECN using the UHPLC-ESI procedure.

NumberFlavonoid-based bioactive compoundsAntinociceptive model usedAntinociceptive activity reported by

(1)Gallic acid(i) Inflammatory pain modelTrevisan et al. [21]
(ii) Carrageenan-induced hyperalgesia test
(iii) Neuropathic pain model
(iv) Chronic constriction injury (CCI)-induced neuropathic pain test
(v) Cold allodynia test
(vi) Mechanical allodynia test

(2)Caffeic acid(i) Acetic acid-induced writhing testMehrotra et al. [22]
(ii) Formalin-induced paw licking test
(iii) Hot plate test
(iv) Tail flick test

(3)Ferulic acid(i) Neuropathic pain modelXu et al. [23]
(ii) CCI-induced neuropathic pain test
(iii) Mechanical allodynia test
(iv) Thermal hyperalgesia
(v) Electronic von Frey test
(vi) Hot plate test

(4)Vitexin(i) Mechanical hyperalgesia testZhu et al. [24]
(ii) Electronic von Frey test
(iii) Acetic acid-induced writhing test
(iv) Capsaicin-induced nociceptive testBorghi et al. [25]
(v) Formalin test

(5)Orientin(i) Acetic acid-induced writhing testDa Silva et al. [26]
(ii) Capsaicin-induced nociceptive test
(iii) Glutamate-induced nociceptive test

(6)Luteolin(i) CCI-induced neuropathic pain testHara et al. [27]
(ii) Mechanical hyperalgesia
(iii) Electronic von Frey test
(iv) Thermal hyperalgesia
(v) Hot plate test
(vi) Cold hyperalgesia
(vii) Cold plate test

(7)Apigenin(i) Acetic acid-induced writhing testPinheiro et al. [28]
(ii) Formalin-induced paw licking test
(iii) Hot plate test

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