Pain Research and Management / 2019 / Article / Tab 7

Review Article

An Overview of Systematic Reviews of Randomized Controlled Trials on Acupuncture Treating Migraine

Table 7

MAs outcomes about adverse events.

Study IDOutcomeAcute or preventive treatmentInterventionControlFollow-up timeRCTs (n)I2ModelScaleEffect95% CI value

Linde et al. [14]Number of patients reporting adverse effectsNDAcupunctureNR4 (838)73%FEMOR0.47[0.34, 0.65]<0.00001
Number of patients dropping out due to adverse effectsNR2 (191)0%FEMOR0.10[0.01, 0.78]0.028

Linde et al. [7]Number of participants dropping out due to adverse effectsPreventive treatmentAcupunctureNR7 (931)0%FEMOR2.84[0.43, 18.71]0.28
Number of participants reporting adverse effects4 (1414)0%FEMOR1.15[0.85, 1.56]0.35
Number of participants with serious adverse events6 (1071)0%FEMOR1.29[0.43, 3.83]0.65
Number of participants dropping out due to adverse effectsNR4 (451)0%REMOR0.27[0.08, 0.86]0.027
Number of participants reporting adverse effects5 (931)78%REMOR0.25[0.10, 0.62]0.0027
Number of participants with serious adverse events3 (721)0%REMOR1.33[0.38, 4.73]0.66

Chen [16]Number of adverse effectsNDAcupunctureNDNR5 (567)0%FEMRR0.11[0.03, 0.49]0.003

Pu [24]Rate of adverse eventsPreventive treatmentAcupunctureNR7 (1126)77%REMRR0.33[0.17, 0.64]0.001

NR: not reported; ND: not defined; ①: sham acupuncture; ②: drug treatment; FEM: fixed effects model; REM: random effects model.

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