Skin/Muscle Incision and Retraction Induces Evoked and Spontaneous Pain in Mice

Figure 6

Systemic administration of gabapentin did not induce the place preference to the drug-paired chamber. (a) Mice that received sham treatments spent equal amounts of time in the chambers during the preconditioning and testing periods (two-way RM ANOVA, pre versus test: F1; 19 = 0.65, ; drug versus saline: F1; 19 = 0.08, , interaction: F1; 19 = 0.42, ; n = 5). (b) No difference was detected in the preference times of the sham group (t-test, ). (c) No place preference was detected after the application of gabapentin (50 mg/kg) to the mice of SMIR (two-way RM ANOVA, pre versus test: F1; 31 = 0.09, ; drug versus saline: F1; 31 = 7.09, , interaction: F1; 31 = 7.76, ; n = 8). (d) No difference was detected in the preference times of the SMIR group (t-test, ). ANOVA, analysis of variance; RM, repeated measures; PI, preference index.

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