Role of p120 Catenin in Epac1-Induced Chronic Postsurgical Pain in Rats

Figure 3

Effects of CPSP on expression of p120 and Epac1 in muscle tissue around postoperative incision and lumbar spinal cord. (a) The expression of p120 in muscle tissue was decreased significantly on the 3rd and 14th day in the SMIR group, , vs. naive group. (b) The expression of Epac1 in muscle tissue was increased dramatically on the 3rd and 14th day and was decreased significantly on the 7th day after operation in the SMIR group, vs. naive group. (c) The expression of p120 in the spinal cord was decreased significantly on the 3rd and 7th day in the SMIR group, , vs. naive group. (d) The expression of Epac1 in spinal cord was increased dramatically on the 3rd and 14th day and was decreased significantly on the 7th day after operation in the SMIR group, vs. naive group. Data information in (a-b): error bars indicate SEM derived from at least three independent experiments, and significance was calculated by one-way analysis of variance ().

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